Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models

被引：14

作者：

Bozorov, Kh A. ^{[1
]}

Mamadalieva, N. Z. ^{[1
]}

Elmuradov, B. Zh ^{[1
]}

Triggiani, D. ^{[2
]}

Egamberdieva, D. ^{[3
]}

Tiezzi, A. ^{[2
]}

Aisa, H. A. ^{[4
]}

Shakhidoyatov, Kh M. ^{[1
]}

机构：

[1] S Yu Yunusov Inst Chem Plant Subst AS RUz, Tashkent 100170, Uzbekistan

[2] Univ Tuscia, Largo Univ, Lab Plant Cytol & Biotechnol, Dept Innovat Biol Agrofoods & Forests Syst DIBAF, I-01100 Viterbo, Italy

[3] Natl Univ Uzbekistan, Dept Biotechnol & Microbiol, Tashkent 100174, Uzbekistan

[4] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China

来源：

JOURNAL OF CHEMISTRY | 2013年 / 2013卷

基金：

中国国家自然科学基金;

关键词：

ANTIMICROBIAL ACTIVITY;

D O I：

10.1155/2013/976715

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiopenes (1-4) were synthesized 2,3-disubstituted thieno [2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some compounds enhanced cell proliferation.

引用

页数：6

共 23 条

[1] Synthesis and antimicrobial activity of new pyridothienopyrimidines and pyridothienotriazines [J].

Abdel-Rahman, AE ;

Bakhite, EA ;

Al-Taifi, EA .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2002, 49 (02) :223-231

[2] Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-ones [J].

Alagarsamy, V. ;

Meena, S. ;

Ramseshu, K. V. ;

Solomon, V. R. ;

Thirumurugan, K. ;

Dhanabal, K. ;

Murugan, M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) :1293-1300

[3]

Ammar YA, 2002, INDIAN J CHEM B, V41, P1486

[4]

Bhuiyan M. M. H., 2005, J APPL SCI RES, V1, P218

[5]

Bhuiyan MMH, 2005, CROAT CHEM ACTA, V78, P633

[6] Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents [J].

Chambhare, RV ;

Khadse, BG ;

Bobde, AS ;

Bahekar, RH .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (01) :89-100

[7]

Chambhare RV, 2002, INDIAN J HETEROCY CH, V12, P67

[8] SATURATED HETEROCYCLES .75. PREPARATION OF TETRACYCLIC THIOPHENE DERIVATIVES WITH BRIDGEHEAD NITROGEN - SYNTHESIS OF POLYMETHYLENETHIENO[2,3-D]DIHYDROPYRROLO-, TETRAHYDROPYRIDO- AND TETRAHYDROAZEPINO[1,2-A]PYRIMIDIN-4-ONES AND -4-THIONES [J].

CSUKONYI, K ;

LAZAR, J ;

BERNATH, G ;

HERMECZ, I ;

MESZAROS, Z .

MONATSHEFTE FUR CHEMIE, 1986, 117 (11) :1295-1303

[9] THIENO[2,3-d]PYRIMIDIN-4-ONES 1. CONDENSATION OF 2,3-DIMETHYL- AND 2,3-TRI-, 2,3-TETRA-, AND 2,3-PENTAMETHYLENE-7,8-DIHYDRO-PYRROLO[1,2-a]THIENO[2,3-d]PYRIMINIDIN-4(6H)-ONES WITH AROMATIC ALDEHYDES AND FURFURAL [J].

Elmuradov, B. Zh. ;

Bozorov, Kh. A. ;

Shakhidoyatov, Kh. M. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2011, 46 (11) :1393-1399

[10] 2-AMINO-THIOPHENE AUS METHYLENAKTIVEN NITRILEN CARBONYLVERBINDUNGEN UND SCHWEFEL [J].

GEWALD, K ;

SCHINKE, E ;

BOTTCHER, H .

CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (01) :94-&

← 1 2 3 →