Clinical Heterogeneity of Desmoplastic Infantile Ganglioglioma: A Case Series and Literature Review

被引：22

作者：

Hummel, Trent R. ^{[1
]}

Miles, Lili ^{[2
]}

Mangano, Francesco T. ^{[3
]}

Jones, Blaise V. ^{[4
]}

Geller, James I. ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Oncol, Canc & Blood Dis Inst, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Pathol & Lab Med, Cincinnati, OH 45229 USA

[3] Cincinnati Childrens Hosp Med Ctr, Dept Pediat Neurol Surg, Cincinnati, OH 45229 USA

[4] Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Cincinnati, OH 45229 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2012年 / 34卷 / 06期

关键词：

desmoplastic infantile ganglioglioma; pediatric; brain tumor; cancer; SUPRATENTORIAL NEUROEPITHELIAL TUMORS; HISTOLOGICAL-FINDINGS; CEREBRAL ASTROCYTOMA; BRAIN-TUMORS; FEATURES; DIAGNOSIS; INFANCY; MRI; MANAGEMENT; SPECTRUM;

D O I：

10.1097/MPH.0b013e3182580330

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Desmoplastic infantile gangliogliomas (DIG) are intracranial tumors described in 1987 as benign lesions of infancy. A literature review and the clinical course of 3 patients reported herein suggest that the initial description should be amended. Nearly 23% of DIG cases occur in children older than 24 months. Approximately 40% of DIG cases require additional medical, radiation, and/or further surgical intervention, and 15% of infants and children develop leptomeningeal spread or die from DIG. Such adverse outcomes, combined with the recognition that DIG represents a heterogeneous disease, underscore the need for an expanded biological and molecular investigation.

引用

页码：E232 / E236

页数：5

共 57 条

[21] Unique desmoplastic cerebral tumor in a patient with complex partial seizures [J].

Jay, V ;

Edwards, V ;

Rutka, J ;

Mosskin, M ;

Hwang, P ;

Resch, L .

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 1998, 1 (03) :234-242

[22] Atypical MRI appearance of desmoplastic infantile ganglioglioma [J].

Kesavadas, C ;

Sonwalker, H ;

Thomas, B ;

Gupta, AL ;

Radhakrishnan, VV .

PEDIATRIC RADIOLOGY, 2005, 35 (10) :1024-1026

[23]

Khaddage Abir, 2004, Ann Diagn Pathol, V8, P280, DOI 10.1016/j.anndiagpath.2004.07.004

[24] Case of desmoplastic infantile ganglioglioma secreting ceruloplasmin [J].

Knapp, J ;

Olson, L ;

Tye, S ;

Bethard, JR ;

Welsh, CA ;

Rumbolt, Z ;

Takacs, I ;

Maria, BL .

JOURNAL OF CHILD NEUROLOGY, 2005, 20 (11) :920-924

[25] Mixed conventional and desmoplastic infantile ganglioglioma: an autopsied case with 6-year follow-up [J].

Komori, T ;

Scheithauer, BW ;

Parisi, JE ;

Watterson, J ;

Priest, JR .

MODERN PATHOLOGY, 2001, 14 (07) :720-726

[26] Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics [J].

Kros, JM ;

Delwel, EJ ;

de Jong, THR ;

Tanghe, HLJ ;

van Run, PRWA ;

Vissers, K ;

Alers, JC .

ACTA NEUROPATHOLOGICA, 2002, 104 (02) :144-148

[27] DESMOPLASTIC GANGLIOGLIOMA - REPORT OF 2 NONINFANTILE CASES [J].

KUCHELMEISTER, K ;

BERGMANN, M ;

VONWILD, K ;

HOCHREUTHER, D ;

BUSCH, G ;

GULLOTTA, F .

ACTA NEUROPATHOLOGICA, 1993, 85 (02) :199-204

[28] Desmoplastic infantile ganglioglioma (DIG): cranial ultrasound findings [J].

Lababede, O ;

Bardo, D ;

Goske, MJ ;

Prayson, RA .

PEDIATRIC RADIOLOGY, 2001, 31 (06) :403-405

[29] Desmoplastic infantile ganglioglioma:: novel aspects in clinical presentation and genetics [J].

Lonnrot, Kimmo ;

Terho, Markku ;

Kahara, Veikko ;

Haapasalo, Hannu ;

Helen, Pauli .

SURGICAL NEUROLOGY, 2007, 68 (03) :304-308

[30] The management of desmoplastic neuroepithelial tumours in childhood [J].

Mallucci, C ;

Lellouch-Tubiana, A ;

Salazar, C ;

Cinalli, G ;

Renier, D ;

Sainte-Rose, C ;

Pierre-Kahn, A ;

Zerah, M .

CHILDS NERVOUS SYSTEM, 2000, 16 (01) :8-14

← 1 2 3 4 5 6 →