A new pharmacophore of potential antimycobacterial activity: The disulfide group in the ring of alicyclic compounds

被引：11

作者：

Stachel, HD

Odlerova, Z

Waisser, K

机构：

[1] CHARLES UNIV,FAC PHARM,DEPT INORGAN CHEM,HRADEC KRALOVE 50005,CZECH REPUBLIC

[2] UNIV MUNICH,INST PHARM & FOOD CHEM,D-80333 MUNICH,GERMANY

[3] INST PREVENT & CLIN MED,BRATISLAVA 83301,SLOVAKIA

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1997年 / 62卷 / 03期

关键词：

2,3-dithiabicyclo[3.3.0]octa-4,8-dienes; antimycobacterial activity; structure-activity relationships; Free-Wilson analysis;

D O I：

10.1135/cccc19970510

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of thirty 2,3-dithiabicyclo[3.3.0]octa-4,8-diene derivatives was examined for antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. avium, and M. fortuitum. The structure-activity relationships were analysed by Free-Wilson method. The authors consider the disulfide moiety to be the pharmacophore of antimycobacterial activity. To verify the idea, several other monocyclic sulfides, 3,4-dihydro-1,2-dithiolane derivatives, were also evaluated.

引用

页码：510 / 515

页数：6

共 8 条

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