How vision and movement combine in the hippocampal place code

被引:224
作者
Chen, Guifen [1 ]
King, John A. [3 ,4 ]
Burgess, Neil [4 ,5 ]
O'Keefe, John [1 ,2 ]
机构
[1] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England
[2] UCL, Sainsbury Wellcome Ctr Neural Circuits & Behav, London WC1E 6BT, England
[3] UCL, Res Dept Clin Educ & Hlth Psychol, London WC1N 3AR, England
[4] UCL, Inst Cognit Neurosci, London WC1N 3AR, England
[5] UCL, Inst Neurol, London WC1N 3AR, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
FREELY-MOVING RAT; PATH-INTEGRATION; VISUAL LANDMARKS; VIRTUAL-REALITY; ENSEMBLE CODE; CELLS; NAVIGATION; SPACE; NEURONS; FIELDS;
D O I
10.1073/pnas.1215834110
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
How do external environmental and internal movement-related information combine to tell us where we are? We examined the neural representation of environmental location provided by hippocampal place cells while mice navigated a virtual reality environment in which both types of information could be manipulated. Extracellular recordings were made from region CA1 of head-fixed mice navigating a virtual linear track and running in a similar real environment. Despite the absence of vestibular motion signals, normal place cell firing and theta rhythmicity were found. Visual information alone was sufficient for localized firing in 25% of place cells and to maintain a local field potential theta rhythm (but with significantly reduced power). Additional movement-related information was required for normally localized firing by the remaining 75% of place cells. Trials in which movement and visual information were put into conflict showed that they combined nonlinearly to control firing location, and that the relative influence of movement versus visual information varied widely across place cells. However, within this heterogeneity, the behavior of fully half of the place cells conformed to a model of path integration in which the presence of visual cues at the start of each run together with subsequent movement-related updating of position was sufficient to maintain normal fields.
引用
收藏
页码:378 / 383
页数:6
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