Germline polymorphism of cancer susceptibility genes in gynecologic cancer

被引：15

作者：

Ueda, Masatsugu ^{[1
]}

Toji, Eisaku ^{[1
]}

Nunobiki, Osamu ^{[1
]}

Izuma, Shinji ^{[1
]}

Okamoto, Yoshiaki ^{[1
]}

Torii, Kiyo ^{[1
]}

Noda, Sadamu ^{[1
]}

机构：

[1] Osaka Canc Prevent & Detect Ctr, Joto Ku, Osaka 5368588, Japan

来源：

HUMAN CELL | 2008年 / 21卷 / 04期

关键词：

FAS; CD95; glutathione-S-transferase; gynecologic cancer; p53; polymorphism;

D O I：

10.1111/j.1749-0774.2008.00058.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The multifactorial process of carcinogenesis involves mutations in oncogenes, or tumor suppressor genes, as well as the influence of environmental etiological factors. Common DNA polymorphisms in low penetrance genes have emerged as genetic factors that seem to modulate an individual's susceptibility to malignancy. Genetic studies, which lead to a true association, are expected to increase understanding of the pathogenesis of each malignancy and to be a powerful tool for prevention and prognosis in the future. Here, we review the findings of genetic association studies of gene polymorphisms in gynecologic cancer with special reference to glutathione-S-transferase, FAS/CD95 and p53 genes including our recent research results.

引用

页码：95 / 104

页数：10

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