Germline polymorphism of cancer susceptibility genes in gynecologic cancer

被引：15
作者：
Ueda, Masatsugu [1 ]
Toji, Eisaku [1 ]
Nunobiki, Osamu [1 ]
Izuma, Shinji [1 ]
Okamoto, Yoshiaki [1 ]
Torii, Kiyo [1 ]
Noda, Sadamu [1 ]
机构：
[1] Osaka Canc Prevent & Detect Ctr, Joto Ku, Osaka 5368588, Japan
来源：
HUMAN CELL | 2008年 / 21卷 / 04期
关键词：
FAS; CD95; glutathione-S-transferase; gynecologic cancer; p53; polymorphism;
D O I：
10.1111/j.1749-0774.2008.00058.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The multifactorial process of carcinogenesis involves mutations in oncogenes, or tumor suppressor genes, as well as the influence of environmental etiological factors. Common DNA polymorphisms in low penetrance genes have emerged as genetic factors that seem to modulate an individual's susceptibility to malignancy. Genetic studies, which lead to a true association, are expected to increase understanding of the pathogenesis of each malignancy and to be a powerful tool for prevention and prognosis in the future. Here, we review the findings of genetic association studies of gene polymorphisms in gynecologic cancer with special reference to glutathione-S-transferase, FAS/CD95 and p53 genes including our recent research results.
引用
收藏
页码：95 / 104
页数：10
相关论文
共 84 条
  • [1] P53 codon 72 polymorphism and correlation with ovarian and endometrial cancer in Greek women
    Agorastos, T
    Masouridou, S
    Lambropoulos, AF
    Chrisafi, S
    Miliaras, D
    Pantazis, K
    Constantinides, TC
    Kotsis, A
    Bontis, I
    [J]. EUROPEAN JOURNAL OF CANCER PREVENTION, 2004, 13 (04) : 277 - 280
  • [2] Ambrosone CB, 2001, CANCER RES, V61, P7130
  • [3] CODON-72 POLYMORPHISM OF THE TP53 GENE
    ARA, S
    LEE, PSY
    HANSEN, MF
    SAYA, H
    [J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (16) : 4961 - 4961
  • [4] Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
    Baez, S
    SeguraAguilar, J
    Widersten, M
    Johansson, AS
    Mannervik, B
    [J]. BIOCHEMICAL JOURNAL, 1997, 324 : 25 - 28
  • [5] Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival
    Beeghly, A
    Katsaros, D
    Chen, H
    Fracchioli, S
    Zhang, Y
    Massobrio, M
    Risch, H
    Jones, B
    Yu, H
    [J]. GYNECOLOGIC ONCOLOGY, 2006, 100 (02) : 330 - 337
  • [6] Brooks LA, 2000, CANCER RES, V60, P6875
  • [7] Chen C, 1999, AM J EPIDEMIOL, V150, P568
  • [8] Simultaneous characterization of glutathione S-transfersase M1 and T1 polymorphisms by polymerase chain reaction in American whites and blacks
    Chen, CL
    Liu, Q
    Relling, MV
    [J]. PHARMACOGENETICS, 1996, 6 (02): : 187 - 191
  • [9] Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect
    Chen, HW
    Sandler, DP
    Taylor, JA
    Shore, DL
    Liu, E
    Bloomfield, CD
    Bell, DA
    [J]. LANCET, 1996, 347 (8997) : 295 - 297
  • [10] Cheng L, 1999, INT J CANCER, V84, P220, DOI 10.1002/(SICI)1097-0215(19990621)84:3<220::AID-IJC4>3.0.CO
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