Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy

被引:97
作者
Arruda Macedo, Jessica Kele [1 ,2 ,3 ]
Fox, Jay W. [3 ]
Castro, Mariana de Souza [1 ,2 ]
机构
[1] Univ Brasilia, Inst Biol, Dept Cell Biol, Brazilian Ctr Prot Res, Brasilia, DF, Brazil
[2] Univ Brasilia, Inst Biol, Dept Physiol Sci, Toxinol Lab, Brasilia, DF, Brazil
[3] Univ Virginia, Sch Med, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA 22903 USA
关键词
Antitumor; carcinogenesis; cell death; integrins; metastasis; snake venoms; tumor promotion; ENDOTHELIAL GROWTH-FACTOR; TUMOR-CELL DISSEMINATION; V BETA 3; IN-VITRO; HETERODIMERIC DISINTEGRIN; CONTAINING PEPTIDE; ALPHA(V)BETA(3) INTEGRINS; RECOMBINANT DISINTEGRIN; DIMERIC DISINTEGRINS; ADHESION MOLECULES;
D O I
10.2174/1389203716666150515125002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms of novel therapeutic leads for cancer treatment. Disintegrin can target specific integrins and as such it is conceivable that they could interfere in important processes involved in carcinogenesis, tumor growth, invasion and migration. Herein we present a survey of studies involving the use of snake venom disintegrins for cancer detection and treatment. The aim of this review is to highlight the relationship of integrins with cancer and to present examples as to how certain disintegrins can detect and affect biological processes related to cancer. This in turn will illustrate the great potential of these molecules for cancer research. Furthermore, we also outline several new approaches being created to address problems commonly associated with the clinical application of peptide-based drugs such as instability, immunogenicity, and availability.
引用
收藏
页码:532 / 548
页数:17
相关论文
共 178 条
[21]   Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 [J].
Brooks, PC ;
Stromblad, S ;
Sanders, LC ;
vonSchalscha, TL ;
Aimes, RT ;
StetlerStevenson, WG ;
Quigley, JP ;
Cheresh, DA .
CELL, 1996, 85 (05) :683-693
[22]   Snake venom disintegrins:: evolution of structure and function [J].
Calvete, JJ ;
Marcinkiewicz, C ;
Monleón, D ;
Esteve, V ;
Celda, B ;
Juárez, P ;
Sanz, L .
TOXICON, 2005, 45 (08) :1063-1074
[23]   Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering [J].
Calvete, JJ ;
Moreno-Murciano, MP ;
Theakston, RDG ;
Kisiel, DG ;
Marcinkiewicz, C .
BIOCHEMICAL JOURNAL, 2003, 372 :725-734
[24]   The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on aIIbβ3, αvβ3, and α5β3 integrins [J].
Calvete, JJ ;
Fox, JW ;
Agelan, A ;
Niewiarowski, S ;
Marcinkiewicz, C .
BIOCHEMISTRY, 2002, 41 (06) :2014-2021
[25]   Snake venomics of Bitis gabonica gabonica.: Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2 [J].
Calvete, Juan J. ;
Marcinkiewicz, Cezary ;
Sanz, Libia .
JOURNAL OF PROTEOME RESEARCH, 2007, 6 (01) :326-336
[26]   The continuing saga of snake venom disintegrins [J].
Calvete, Juan J. .
TOXICON, 2013, 62 :40-49
[27]   The integrin, α6β1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells [J].
Carloni, V ;
Mazzocca, A ;
Pantaleo, P ;
Cordella, C ;
Laffi, G ;
Gentilini, P .
HEPATOLOGY, 2001, 34 (01) :42-49
[28]   Endocytic transport of integrins during cell migration and invasion [J].
Caswell, Patrick ;
Norman, Jim .
TRENDS IN CELL BIOLOGY, 2008, 18 (06) :257-263
[30]   Inhibitory effect of salmosin, a Korean snake venom-derived disintegrin, on the integrin αv-mediated proliferation of SK-Mel-2 human melanoma cells [J].
Chung, KH ;
Kim, SH ;
Han, KY ;
Sohn, YD ;
Kim, DS ;
Jang, Y ;
Kim, DS ;
Kang, IC .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (11) :1577-1582