Incidence, Prevalence, and Mortality of People with Psoriasis and Psoriatic Arthritis in Taiwan: A Nationwide Cohort Study

There is a recognized need to better understand chang es in the epidemiology of psoriasis and psoria-tic arthritis (PsA) over time in Asia. Using the Taiwan National Health Insurance claim records this popula-tion-based study examined changes in the prevalence, incidence, and mortality rates in patients with pso-riasis or psoriatic arthritis in Taiwan over 12 years. Patients with >= 1 diagnosis code for psoriasis or pso-riatic arthritis, recorded either by dermatologists or rheumatologists, were identified. Annual age-and sex-standardized prevalence and incidence rates were calculated using the Taiwan general population as re-ference. To investigate mortality, each patient in the incident cohort was matched to 10 comparators from the general population by sex and age (at diagnosis). The risk of mortality between study cohorts and com-parators was analysed by Cox proportional hazard reg-ression. The prevalence of psoriasis (0.18-0.86%) and psoriatic arthritis (0.01-0.08%) increased steadily b etween 2006 and 2017. The incidence rates, howe-ver, remained stable (psoriasis: 62-65 per 100,000 person-years; psoriatic arthritis: 6-5 per 100,000 per-son-years). The risk of all-cause mortality for patients with psoriasis (hazard ratio 1.16; 95% confidence interval: 1.13-1.19) was higher than the general po-pulation, despite a decreasing trend over time in the all-cause mortality rates for both groups. The steady increase in the prevalence of psoriasis despite stable incidence rates suggests that improvements in life ex-pectancy may be the key determinant of this increase.