The role of exercise and PGC1α in inflammation and chronic disease

被引：784

作者：

Handschin, Christoph ^{[1
,2
]}

Spiegelman, Bruce M. ^{[3
,4
]}

机构：

[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Zurich Ctr Integrat Human Physiol ZIHP, CH-8057 Zurich, Switzerland

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE | 2008年 / 454卷 / 7203期

关键词：

D O I：

10.1038/nature07206

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1 alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

引用

页码：463 / 469

页数：7

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