The use of principal component analysis for the study of the interaction of anionic surfactants with hydroxypropyl-β-cyclodextrin

The interaction of 11 sulfosuccinic acid ester anionic surfactants with hydroxypropyl-beta-cyclodextrin (HP beta CD) were determined with reversed-phase thin-layer chromacography and the relative strength of interaction was calculated. The relationship between the strength of interaction and the physicochemical parameters of anionic surfactants was elucidated with principal component analysis (PCA). HP beta CD interacted with the anionic surfactants decreasing their hydrophobicity. The distribution of the points of the strength of interaction and physicochemical parameters on the two dimensional nonlinear map of PC loadings suggested that the strength of interaction between the anionic surfactants and HP beta CD is of mixed steric character, with hydrophobic and electronic forces being involved in the interaction.