Long-Term Results of Adipose-Derived Stem Cell Therapy for the Treatment of Crohn's Fistula

被引：143
作者：
Cho, Yong Beom [1 ]
Park, Kyu Joo [2 ]
Yoon, Sang Nam [3 ,4 ]
Song, Kee Ho [5 ]
Kim, Do Sun [5 ]
Jung, Sang Hun [6 ]
Kim, Mihyung [7 ]
Jeong, Hee Young [7 ]
Yu, Chang Sik [3 ,4 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Surg, Seoul, South Korea
[3] Univ Ulsan, Coll Med, Dept Colon & Rectal Surg, Seoul 138736, South Korea
[4] Asan Med Ctr, Seoul 138736, South Korea
[5] Daehang Hosp, Dept Surg, Seoul, South Korea
[6] Yeungnam Univ, Dept Surg, Med Ctr, Daegu, South Korea
[7] Anterogen Co Ltd, Seoul, South Korea
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2015年 / 4卷 / 05期
关键词：
Adipose-derived stem cells; Autologous stem cells; Crohn's fistula; Complete closure of fistula; Sustained response; MESENCHYMAL STROMAL CELLS; COMPLEX PERIANAL FISTULAS; SURGICAL-TREATMENT; SETON TREATMENT; PHASE-I; DISEASE; MANAGEMENT; INFLIXIMAB; CLASSIFICATION; AZATHIOPRINE;
D O I：
10.5966/sctm.2014-0199
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohn's disease, a devastating condition with a high recurrence rate, demonstrated safety and therapeutic potential with a 1-year sustained response. In the present study, 41 of the 43 phase II trial patients were followed for an additional year, regardless of response in the initial year. At 24 months, complete healing was observed in 21 of 26 patients (80.8%) in modified per protocol analysis and 27 of 36 patients (75.0%) in modified intention-to-treat analysis. No adverse events related to ASC administration were observed. Furthermore, complete closure after initial treatment was well-sustained. These results strongly suggest that autologous ASCs may be a novel treatment option for Crohn's fistulae.
引用
收藏
页码：532 / 537
页数：6
相关论文
共 41 条
  • [1] Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: Relevance to tissue engineering human heart valves
    Batten, Puspa
    Sarathchandra, Padmini
    Antoniw, Joseph W.
    Tay, Szun Szun
    Lowdell, Mark W.
    Taylor, Patricia M.
    Yacoub, Magdi H.
    [J]. TISSUE ENGINEERING, 2006, 12 (08): : 2263 - 2273
  • [2] Autologous Adipose Tissue-Derived Stem Cells for the Treatment of Crohn's Fistula: A Phase I Clinical Study
    Cho, Yong Beom
    Lee, Woo Yong
    Park, Kyu Joo
    Kim, Mihyung
    Yoo, Hee-Won
    Yu, Chang Sik
    [J]. CELL TRANSPLANTATION, 2013, 22 (02) : 279 - 285
  • [3] Expansion of Adipose Mesenchymal Stromal Cells Is Affected by Human Platelet Lysate and Plating Density
    Cholewa, Dominik
    Stiehl, Thomas
    Schellenberg, Anne
    Bokermann, Gudrun
    Joussen, Sylvia
    Koch, Carmen
    Walenda, Thomas
    Pallua, Norbert
    Marciniak-Czochra, Anna
    Suschek, Christoph V.
    Wagner, Wolfgang
    [J]. CELL TRANSPLANTATION, 2011, 20 (09) : 1409 - 1422
  • [4] Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease
    Ciccocioppo, Rachele
    Bernardo, Maria Ester
    Sgarella, Adele
    Maccario, Rita
    Avanzini, Maria Antonietta
    Ubezio, Cristina
    Minelli, Antonella
    Alvisi, Costanza
    Vanoli, Alessandro
    Calliada, Fabrizio
    Dionigi, Paolo
    Perotti, Cesare
    Locatelli, Franco
    Corazza, Gino Roberto
    [J]. GUT, 2011, 60 (06) : 788 - 798
  • [5] Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease
    Dejaco, C
    Harrer, M
    Waldhoer, T
    Miehsler, W
    Vogelsang, H
    Reinisch, W
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 18 (11-12) : 1113 - 1120
  • [6] Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
    Duijvestein, Marjolijn
    Vos, Anne Christine W.
    Roelofs, Helene
    Wildenberg, Manon E.
    Wendrich, Barbara B.
    Verspaget, Henricus W.
    Kooy-Winkelaar, Engelina M. C.
    Koning, Frits
    Zwaginga, Jaap Jan
    Fidder, Herma H.
    Verhaar, Auke P.
    Fibbe, Willem E.
    van den Brink, Gijs R.
    Hommes, Daniel W.
    [J]. GUT, 2010, 59 (12) : 1662 - 1669
  • [7] Expanded Adipose-Derived Stem Cells for the Treatment of Complex Perianal Fistula: a Phase II Clinical Trial
    Garcia-Olmo, Damian
    Herreros, Dolores
    Pascual, Isabel
    Antonio Pascual, Jose
    Del-Valle, Emilio
    Zorrilla, Jaime
    De-La-Quintana, Paloma
    Garcia-Arranz, Mariano
    Pascual, Maria
    [J]. DISEASES OF THE COLON & RECTUM, 2009, 52 (01) : 79 - 86
  • [8] Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression
    Ge, Wei
    Jiang, Jifu
    Arp, Jacqueline
    Liu, Weihua
    Garcia, Bertha
    Wang, Hao
    [J]. TRANSPLANTATION, 2010, 90 (12) : 1312 - 1320
  • [9] A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease
    Gecse, Krisztina B.
    Bemelman, Willem
    Kamm, Michael A.
    Stoker, Jaap
    Khanna, Reena
    Ng, Siew C.
    Panes, Julian
    van Assche, Gert
    Liu, Zhanju
    Hart, Ailsa
    Levesque, Barrett G.
    D'Haens, Geert
    [J]. GUT, 2014, 63 (09) : 1381 - 1392
  • [10] Adipose-Derived Mesenchymal Stem Cells Alleviate Experimental Colitis by Inhibiting Inflammatory and Autoimmune Responses
    Gonzalez, Manuel A.
    Gonzalez-Rey, Elena
    Rico, Laura
    Buescher, Dirk
    Delgado, Mario
    [J]. GASTROENTEROLOGY, 2009, 136 (03) : 978 - 989
12345