Long-Term Results of Adipose-Derived Stem Cell Therapy for the Treatment of Crohn's Fistula

被引：146

作者：

Cho, Yong Beom ^{[1
]}

Park, Kyu Joo ^{[2
]}

Yoon, Sang Nam ^{[3
,4
]}

Song, Kee Ho ^{[5
]}

Kim, Do Sun ^{[5
]}

Jung, Sang Hun ^{[6
]}

Kim, Mihyung ^{[7
]}

Jeong, Hee Young ^{[7
]}

Yu, Chang Sik ^{[3
,4
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Surg, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Dept Colon & Rectal Surg, Seoul 138736, South Korea

[4] Asan Med Ctr, Seoul 138736, South Korea

[5] Daehang Hosp, Dept Surg, Seoul, South Korea

[6] Yeungnam Univ, Dept Surg, Med Ctr, Daegu, South Korea

[7] Anterogen Co Ltd, Seoul, South Korea

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2015年 / 4卷 / 05期

关键词：

Adipose-derived stem cells; Autologous stem cells; Crohn's fistula; Complete closure of fistula; Sustained response; MESENCHYMAL STROMAL CELLS; COMPLEX PERIANAL FISTULAS; SURGICAL-TREATMENT; SETON TREATMENT; PHASE-I; DISEASE; MANAGEMENT; INFLIXIMAB; CLASSIFICATION; AZATHIOPRINE;

D O I：

10.5966/sctm.2014-0199

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohn's disease, a devastating condition with a high recurrence rate, demonstrated safety and therapeutic potential with a 1-year sustained response. In the present study, 41 of the 43 phase II trial patients were followed for an additional year, regardless of response in the initial year. At 24 months, complete healing was observed in 21 of 26 patients (80.8%) in modified per protocol analysis and 27 of 36 patients (75.0%) in modified intention-to-treat analysis. No adverse events related to ASC administration were observed. Furthermore, complete closure after initial treatment was well-sustained. These results strongly suggest that autologous ASCs may be a novel treatment option for Crohn's fistulae.

引用

页码：532 / 537

页数：6

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