The role of B cells in COVID-19 infection and vaccination

被引：58

作者：

Chen, Shiru ^{[1
,2
]}

Guan, Fei ^{[1
]}

Candotti, Fabio ^{[3
]}

Benlagha, Kamel ^{[4
]}

Camara, Niels Olsen Saraiva ^{[5
]}

Herrada, Andres A. ^{[6
]}

James, Louisa K. ^{[7
]}

Lei, Jiahui ^{[1
]}

Miller, Heather ^{[8
]}

Kubo, Masato ^{[9
]}

Ning, Qin ^{[10
]}

Liu, Chaohong ^{[1
]}

机构：

[1] Huazhong Univ Sci Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Internal Med, Div Gastroenterol & Hepatol, Wuhan, Peoples R China

[3] Univ Lausanne, Lausanne Univ Hosp, Div Immunol & Allergy, Lausanne, Switzerland

[4] Univ Paris, Inst Rech St Louis, Paris, France

[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Human Immunol, Sao Paulo, SP, Brazil

[6] Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Lymphat & Inflammat Res Lab, Talca, Chile

[7] Queen Mary Univ London, Bizard Inst, Ctr Immunobiol, London, England

[8] Cytek Biosci, R&D Clin Reagents, Fremont, CA USA

[9] Inst Phys & Chem Res RIKEN, Yokohama Inst, Ctr Integrat Med Sci IMS, Lab Cytokine Regulat, Yokohama, Kanagawa, Japan

[10] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Infect Dis, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

B cells; antibody; COVID-19; SARS-CoV-2; memory B cells; vaccination; NEUTROPHIL EXTRACELLULAR TRAPS; ACUTE RESPIRATORY SYNDROME; GERMINAL-CENTERS; SARS-COV-2; INFECTION; MARGINAL ZONE; MEMORY; ANTIBODY; RESPONSES; IMMUNITY; HYPERMUTATION;

D O I：

10.3389/fimmu.2022.988536

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.

引用

页数：13

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