Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo

被引：87

作者：

Yildirim, Senay ^{[1
,2
]}

Altun, Seyhan ^{[2
]}

Gumushan, Hatice ^{[2
,3
]}

Patel, Anup ^{[4
]}

Djamgoz, Mustafa B. A. ^{[1
,5
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Nat Sci, Div Cell & Mol Biol, London SW7 2AZ, England

[2] Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey

[3] Harran Univ, Fac Sci & Arts, Dept Biol, Sanliurfa, Turkey

[4] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Urol, London W2 1NY, England

[5] Cyprus Int Univ, Biotechnol Res Ctr, TR-10 N Cyprus, Mersin, Turkey

来源：

CANCER LETTERS | 2012年 / 323卷 / 01期

关键词：

Prostate cancer; Metastasis; Dunning cell; Mat-LyLu; Voltage-gated sodium channel; Tetrodotoxin; CELL-LINES; BREAST-CANCER; EXPRESSION; RAT; VITRO; INVASIVENESS; INVASION; NAV1.5; GENES;

D O I：

10.1016/j.canlet.2012.03.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggested that functional VGSC expression enhances various in vitro cell behaviours, such as directional motility, that would be involved in the metastatic cascade. However, it is not known if VGSC activity promotes metastasis in vivo. Here, using the Copenhagen rat model of prostate cancer and blocking VGSC activity in primary tumours with tetrodotoxin, we show (1) that the number of lung metastasis is reduced by >40% and (2) that lifespan is significantly improved. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：58 / 61

页数：4

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