Elevated expression of FABP4 is associated with disease activity in rheumatoid arthritis patients

被引：13

作者：

Chen, Shuaishuai ^{[1
]}

Du, Juping ^{[1
]}

Zhao, Weibo ^{[2
]}

Cao, Rong ^{[1
]}

Wang, Na ^{[1
]}

Li, Jun ^{[1
]}

Shen, Bo ^{[1
]}

Chen, Shiyong ^{[1
]}

机构：

[1] Wenzhou Med Univ, Dept Clin Lab, Taizhou Hosp Zhejiang Prov, Linhai 317000, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Orthopaed Surg, Linhai 317000, Zhejiang, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 15期

关键词：

DAS28; score; disease activity; fatty acid-binding protein 4; rheumatoid arthritis; ACID-BINDING PROTEIN; PPAR-GAMMA; INFLAMMATION; ACTIVATION; BIOMARKER;

D O I：

10.2217/bmm-2020-0284

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Data from 124 rheumatoid arthritis (RA) patients and 69 healthy controls were collected. Materials & methods: ELISA was performed to detect serum FABP4 levels. Results: FABP4 level was elevated in RA patients and positively associated with 28-joint disease activity score, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, total cholesterol, triglyceride and low-density lipoprotein cholesterol. Additionally, the area under the receiver operating characteristic curve for FABP4 was 0.685 for RA patients versus healthy controls (p = 0.001). RA patients were separated into low, moderate and high disease activity based on 28-joint disease activity score. The area under the receiver operating characteristic value was 0.877 for RA patients with high disease activity versus healthy controls (p < 0.001). Conclusion: FABP4 was associated with disease activity in RA patients.

引用

收藏

页码：1405 / 1413

页数：9

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