Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters

被引:153
作者
Machnicka, Beata [2 ]
Czogalla, Aleksander [1 ]
Hryniewicz-Jankowska, Anita [1 ]
Boguslawska, Dzamila M. [2 ]
Grochowalska, Renata [2 ]
Heger, Elzbieta [2 ]
Sikorski, Aleksander F. [1 ]
机构
[1] Univ Wroclaw, Biotechnol Fac, PL-50138 Wroclaw, Poland
[2] Univ Zielona Gora, Fac Biol Sci, Zielona Gora, Poland
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2014年 / 1838卷 / 02期
关键词
Spectrin; Spectrin-based membrane skeleton; Plasma membrane domain; ALPHA-II-SPECTRIN; HUMAN-ERYTHROCYTE-MEMBRANE; ATOMIC-FORCE MICROSCOPY; CELL-ADHESION MOLECULE; ACTIN-BINDING DOMAIN; ATAXIA TYPE 5; NONERYTHROID BETA-SPECTRIN; PLECKSTRIN HOMOLOGY DOMAIN; AXON INITIAL SEGMENTS; CROSS-LINK REPAIR;
D O I
10.1016/j.bbamem.2013.05.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review focuses on structure and functions of spectrin as a major component of the membrane skeleton. Recent advances on spectrin function as an interface for signal transduction mediation and a number of data concerning interaction of spectrin with membrane channels, adhesion molecules, receptors and transporters draw a picture of multifaceted protein. Here, we attempted to show the current depiction of multitask role of spectrin in cell physiology. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Herve. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:620 / 634
页数:15
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