Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

被引：575
作者：
Bond, Allison M. [1 ,2 ]
Ming, Guo-li [1 ,2 ,3 ,4 ]
Song, Hongjun [1 ,2 ,3 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Solomon Snyder Dept Neurosci, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
来源：
CELL STEM CELL | 2015年 / 17卷 / 04期
关键词：
HIPPOCAMPAL NEUROGENESIS; SUBVENTRICULAR ZONE; EMBRYONIC ORIGIN; VASCULAR NICHE; STEM/PROGENITOR CELLS; EPIGENETIC REGULATION; EXTRACELLULAR-MATRIX; POSTNATAL SVZ; SELF-RENEWAL; HUMAN BRAIN;
D O I：
10.1016/j.stem.2015.09.003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.
引用
收藏
页码：385 / 395
页数：11
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