β-Amyloid accumulation in the human brain after one night of sleep deprivation

被引：610

作者：

Shokri-Kojori, Ehsan ^{[1
]}

Wang, Gene-Jack ^{[1
]}

Wiers, Corinde E. ^{[1
]}

Demiral, Sukru B. ^{[1
]}

Guo, Min ^{[1
]}

Kim, Sung Won ^{[1
]}

Lindgren, Elsa ^{[1
]}

Ramirez, Veronica ^{[1
]}

Zehra, Amna ^{[1
]}

Freeman, Clara ^{[1
]}

Miller, Gregg ^{[1
]}

Manza, Peter ^{[1
]}

Srivastava, Tansha ^{[1
]}

De Santi, Susan ^{[2
]}

Tomasi, Dardo ^{[1
]}

Benveniste, Helene ^{[3
]}

Volkow, Nora D. ^{[1
]}

机构：

[1] NIAAA, Lab Neuroimaging, NIH, Bethesda, MD 20892 USA

[2] Piramal Pharma Inc, Boston, MA 02108 USA

[3] Yale Sch Med, Dept Anesthesiol, New Haven, CT 06510 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2018年 / 115卷 / 17期

关键词：

beta amyloid; sleep; hippocampus; Alzheimer's disease; glymphatic system; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; A-BETA; MOUSE MODEL; PET; DISTURBANCE; QUALITY; NEUROINFLAMMATION; F-18-FLORBETABEN; DEPOSITION;

D O I：

10.1073/pnas.1721694115

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effects of acute sleep deprivation on beta-amyloid (A beta) clearance in the human brain have not been documented. Here we used PET and F-18-florbetaben to measure brain A beta burden (ABB) in 20 healthy controls tested after a night of rested sleep (baseline) and after a night of sleep deprivation. We show that one night of sleep deprivation, relative to baseline, resulted in a significant increase in A beta burden in the right hippocampus and thalamus. These increases were associated with mood worsening following sleep deprivation, but were not related to the genetic risk (APOE genotype) for Alzheimer's disease. Additionally, baseline ABB in a range of subcortical regions and the precuneus was inversely associated with reported night sleep hours. APOE genotyping was also linked to subcortical ABB, suggesting that different Alzheimer's disease risk factors might independently affect ABB in nearby brain regions. In summary, our findings show adverse effects of one-night sleep deprivation on brain ABB and expand on prior findings of higher A beta accumulation with chronic less sleep.

引用

页码：4483 / 4488

页数：6

共 71 条

[1] Neural synchronization in Alzheimer's disease [J].

Aron, Liviu ;

Yankner, Bruce A. .

NATURE, 2016, 540 (7632) :207-208

[2] Neuronal activity regulates the regional vulnerability to amyloid-β deposition [J].

Bero, Adam W. ;

Yan, Ping ;

Roh, Jee Hoon ;

Cirrito, John R. ;

Stewart, Floy R. ;

Raichle, Marcus E. ;

Lee, Jin-Moo ;

Holtzman, David M. .

NATURE NEUROSCIENCE, 2011, 14 (06) :750-U353

[3] The Relationship between Sleep Quality and Brain Amyloid Burden [J].

Brown, Belinda M. ;

Rainey-Smith, Stephanie R. ;

Villemagne, Victor L. ;

Weinborn, Michael ;

Bucks, Romola S. ;

Sohrabi, Hamid R. ;

Laws, Simon M. ;

Taddei, Kevin ;

Macaulay, S. Lance ;

Ames, David ;

Fowler, Christopher ;

Maruff, Paul ;

Masters, Colin L. ;

Rowe, Christopher C. ;

Martins, Ralph N. .

SLEEP, 2016, 39 (05) :1063-1068

[4] Blood-derived amyloid-β protein induces Alzheimer's disease pathologies [J].

Bu, X-L ;

Xiang, Y. ;

Jin, W-S ;

Wang, J. ;

Shen, L-L ;

Huang, Z-L ;

Zhang, K. ;

Liu, Y-H ;

Zeng, F. ;

Liu, J-H ;

Sun, H-L ;

Zhuang, Z-Q ;

Chen, S-H ;

Yao, X-Q ;

Giunta, B. ;

Shan, Y-C ;

Tan, J. ;

Chen, X-W ;

Dong, Z-F ;

Zhou, H-D ;

Zhou, X-F ;

Song, W. ;

Wang, Y-J .

MOLECULAR PSYCHIATRY, 2018, 23 (09) :1948-1956

[5]

Bullich S, 2017, J NUCL MED

[6]

Bullich S, 2017, J NUCL MED

[7] THE PITTSBURGH SLEEP QUALITY INDEX - A NEW INSTRUMENT FOR PSYCHIATRIC PRACTICE AND RESEARCH [J].

BUYSSE, DJ ;

REYNOLDS, CF ;

MONK, TH ;

BERMAN, SR ;

KUPFER, DJ .

PSYCHIATRY RESEARCH, 1989, 28 (02) :193-213

[8] Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease [J].

Cai, Zhiyou ;

Hussain, M. Delwar ;

Yan, Liang-Jun .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2014, 124 (05) :307-321

[9] Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment [J].

Camus, V. ;

Payoux, P. ;

Barre, L. ;

Desgranges, B. ;

Voisin, T. ;

Tauber, C. ;

La Joie, R. ;

Tafani, M. ;

Hommet, C. ;

Chetelat, G. ;

Mondon, K. ;

de la Sayette, V. ;

Cottier, J. P. ;

Beaufils, E. ;

Ribeiro, M. J. ;

Gissot, V. ;

Vierron, E. ;

Vercouillie, J. ;

Vellas, B. ;

Eustache, F. ;

Guilloteau, D. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (04) :621-631

[10] Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance [J].

Castellano, Joseph M. ;

Kim, Jungsu ;

Stewart, Floy R. ;

Jiang, Hong ;

DeMattos, Ronald B. ;

Patterson, Bruce W. ;

Fagan, Anne M. ;

Morris, John C. ;

Mawuenyega, Kwasi G. ;

Cruchaga, Carlos ;

Goate, Alison M. ;

Bales, Kelly R. ;

Paul, Steven M. ;

Bateman, Randall J. ;

Holtzman, David M. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (89)

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