A Facile Method to Prepare Dihydroflavonol Derivatives

被引：1
|
作者：
Zhou, Zongbao [1 ]
Wang, Hong [1 ]
Tao, Kaiqi [1 ]
Ye, Xiaochuan [1 ]
Hu, Chunling [1 ]
机构：
[1] Hubei Univ Tradit Chinese Med, Coll Pharm, Key Lab Chinese Med Chem & Chinese Herbal Compoun, Wuhan 430065, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 36卷 / 11期
基金：
中国国家自然科学基金;
关键词：
2 '-hydroxyl chalcone derivatives; dihydroflavonol derivatives; facile method; CHALCONES; PROLIFERATION; FLAVANONES;
D O I：
10.6023/cjoc201605044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of dihydroflavonol derivatives were synthesized by the reaction of 2'-hydroxyl chalcone derivatives with H2O2/(CH3CH2)(2)NH system in anhydrous tetrahydrofuran under low temperature. The influences of reaction temperature, reaction solvents, the kinds and proportion of alkaline additive and oxidants on this reaction were investigated, and the optimal reaction conditions were determined. This method has the advantages of simple operation, mild conditions and convenient post-treatment. Besides, all synthetic products were fully characterized by NMR spectra.
引用
收藏
页码：2752 / 2756
页数：5
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