Cancer Stem Cells in Solid Tumors: An Overview

被引：143

作者：

O'Brien, Catherine Adell ^{[1
]}

Kreso, Antonija ^{[2
]}

Dick, John E. ^{[1
,2
]}

机构：

[1] Toronto Gen Hosp, Univ Hlth Network, Dept Gen Surg, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada

来源：

SEMINARS IN RADIATION ONCOLOGY | 2009年 / 19卷 / 02期

关键词：

ACUTE MYELOID-LEUKEMIA; SIDE POPULATION CELLS; BREAST-CANCER; SELF-RENEWAL; IDENTIFICATION; CD44; HYPOTHESIS; RESISTANCE; HIERARCHY; GROWTH;

D O I：

10.1016/j.semradonc.2008.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has long been appreciated that significant functional and morphologic heterogeneity can exist within the individual cells that comprise a tumor. Increasing evidence indicates that many solid tumors are organized in a hierarchical manner in which tumor growth is driven by a small subset of cancer stem cells (CSCs) or tumor-initiating cells. Although these cells represent a small percentage of the overall tumor population, they are the only cells capable of initiating and driving tumor growth. Emerging evidence indicates that these cells are also resistant to chemotherapy and radiation therapy, which has led to much speculation and interest surrounding the potential clinical applicability of CSCs. Semin Radiat Oncol 19:71-77 (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：71 / 77

页数：7

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