Cytotoxic Yohimbine-Type Alkaloids from the Leaves of Rauvolfia vomitoria

被引：10

作者：

Zhan, Guanqun ^{[1
]}

Miao, Rongkun ^{[1
]}

Zhang, Fuxin ^{[1
]}

Wang, Xingbin ^{[1
]}

Zhang, Xinxin ^{[1
]}

Guo, Zengjun ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2020年 / 17卷 / 12期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Apocynaceae; Rauvolfia vomitoria; monoterpene indole alkaloids; yohimbine-type alkaloids; cytotoxicity; MONOTERPENOID INDOLE ALKALOIDS; ASPIDOSPERMA;

D O I：

10.1002/cbdv.202000647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new yohimbine-type monoterpene indole alkaloids, rauvines A and B, and six known derivatives were obtained from the leaves of R. vomitoria. The structures of rauvines A and B were determined by extensive spectroscopic analyses, C-13-NMR, and ECD calculations. This is the first time to determine the absolute configurations of yohimbine-type N-oxides by quantum chemistry calculations (C-13-NMR and ECD calculations). All the isolates were tested for their cytotoxicity against five human cancer cell lines. Rauvine B showed moderate cytotoxicity on human MCF-7 breast, SWS80 colon, and A549 lung cancer cell lines with IC50 values of 25.5, 22.6, and 26.0 mu M, respectively.

引用

页数：9

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