A new triterpenoid saponin from Ardisia gigantifolia

被引：15

作者：

Mu, Li-Hua ^{[1
]}

Huang, Xiao-Wu ^{[2
]}

Guo, Dai-Hong ^{[1
]}

Dong, Xian-Zhe ^{[1
]}

Liu, Ping ^{[1
]}

机构：

[1] Gen Hosp PLA, Dept Clin Pharmacol, Beijing 100853, Peoples R China

[2] Gen Hosp PLA, Med Mat Ctr, Beijing 100853, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2013年 / 15卷 / 10期

关键词：

Ardisia gigantifolia; triterpenoid saponin; cytotoxic activity; CYTOTOXIC ACTIVITY;

D O I：

10.1080/10286020.2013.817390

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new triterpenoid saponin, named 3-O--d-glucopyranosyl-(13)--d-xylopyranosyl-(12)-[-l-rhamnopyranosyl-(13)]--d-glucopyranosyl-(14)-[-d-glucopyranosyl-(12)]--l-arabinopyranosyl-3,16,28,30-tetrahydroxy-olean-12-ene (1), along with four known triterpenoids (2-5), was isolated from the rhizomes of Ardisia gigantifolia. Their structures were elucidated by spectroscopic methods. Compounds 1-4 showed cytotoxic activity against Hela, EJ, BCG, and HepG-2 cell lines. The percentage of early apoptotic cells after treatment with 1 was significantly increased compared with control cells (p<0.05).

引用

页码：1123 / 1129

页数：7