Tracking immune cells in vivo using magnetic resonance imaging

被引：383

作者：

Ahrens, Eric T. ^{[1
]}

Bulte, Jeff W. M. ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Dept Radiol & Radiol Sci,Div MR Res,Dept Oncol, Dept Chem & Biomol Engn,Inst Cell Engn,Sch Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Cellular Imaging Sect & Vasc Biol Program, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 10期

基金：

美国国家卫生研究院;

关键词：

SUPERPARAMAGNETIC IRON-OXIDE; INFLAMMATORY-BOWEL-DISEASE; NEURAL STEM-CELLS; DENDRITIC CELLS; T-CELLS; NONINVASIVE DETECTION; CONTRAST AGENTS; MULTIPLE-SCLEROSIS; GENE-EXPRESSION; F-19; MRI;

D O I：

10.1038/nri3531

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The increasing complexity of in vivo imaging technologies, coupled with the development of cell therapies, has fuelled a revolution in immune cell tracking in vivo. Powerful magnetic resonance imaging (MRI) methods are now being developed that use iron oxide- and F-19-based probes. These MRI technologies can be used for image-guided immune cell delivery and for the visualization of immune cell homing and engraftment, inflammation, cell physiology and gene expression. MRI-based cell tracking is now also being applied to evaluate therapeutics that modulate endogenous immune cell recruitment and to monitor emerging cellular immunotherapies. These recent uses show that MRI has the potential to be developed in many applications to follow the fate of immune cells in vivo.

引用

页码：755 / 763

页数：9

共 84 条

[1] In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection [J].

Aarntzen, Erik H. J. G. ;

Srinivas, Mangala ;

Walczak, Piotr ;

Janowski, Miroslaw ;

Heerschap, Arend ;

de Vries, I. Jolanda M. ;

Figdor, Carl G. ;

Bulte, Jeff W. M. ;

Oyen, Wim J. G. .

JOURNAL OF NUCLEAR MEDICINE, 2012, 53 (12) :1825-1828

[2]

Ahrens E. T., 2003, US Patent, Patent No. [10/384,496, 10384496]

[3] Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance [J].

Ahrens, Eric T. ;

Young, Won-Bin ;

Xu, Hongyan ;

Pusateri, Lisa K. .

BIOTECHNIQUES, 2011, 50 (04) :229-234

[4] In vivo imaging platform for tracking immunotherapeutic cells [J].

Ahrens, ET ;

Flores, R ;

Xu, HY ;

Morel, PA .

NATURE BIOTECHNOLOGY, 2005, 23 (08) :983-987

[5] Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging [J].

Ahrens, ET ;

Feili-Hariri, M ;

Xu, H ;

Genove, G ;

Morel, PA .

MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (06) :1006-1013

[6] MRI biosensor for protein kinase A encoded by a single synthetic gene [J].

Airan, Raag D. ;

Bar-Shir, Amnon ;

Liu, Guanshu ;

Pelled, Galit ;

McMahon, Michael T. ;

van Zijl, Peter C. M. ;

Bulte, Jeff W. M. ;

Gilad, Assaf A. .

MAGNETIC RESONANCE IN MEDICINE, 2012, 68 (06) :1919-1923

[7] Magnetic resonance imaging of labeled T-Cells in a mouse model of multiple sclerosis [J].

Anderson, SA ;

Shukaliak-Quandt, J ;

Jordan, EK ;

Arbab, AS ;

Martin, R ;

McFarland, H ;

Frank, JA .

ANNALS OF NEUROLOGY, 2004, 55 (05) :654-659

[8] Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride [J].

Aoki, I ;

Yoshiyuki, T ;

Chuang, KH ;

Silva, AC ;

Igarashi, T ;

Tanaka, C ;

Childs, RW ;

Koretsky, AP .

NMR IN BIOMEDICINE, 2006, 19 (01) :50-59

[9] Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells [J].

Arbab, AS ;

Yocum, GT ;

Rad, AM ;

Khakoo, AY ;

Fellowes, V ;

Read, EJ ;

Frank, JA .

NMR IN BIOMEDICINE, 2005, 18 (08) :553-559

[10] Transforming Thymidine into a Magnetic Resonance Imaging Probe for Monitoring Gene Expression [J].

Bar-Shir, Amnon ;

Liu, Guanshu ;

Liang, Yajie ;

Yadav, Nirbhay N. ;

McMahon, Michael T. ;

Walczak, Piotr ;

Nimmagadda, Sridhar ;

Pomper, Martin G. ;

Tallman, Keri A. ;

Greenberg, Marc M. ;

van Zijl, Peter C. M. ;

Bulte, Jeff W. M. ;

Gilad, Assaf A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (04) :1617-1624

← 1 2 3 4 5 6 7 8 9 →