Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

被引：30
作者：
Guise, Amanda J. [1 ]
Budayeva, Hanna G. [1 ]
Diner, Benjamin A. [1 ]
Cristea, Ileana M. [1 ]
机构：
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
来源：
VIRUSES-BASEL | 2013年 / 5卷 / 07期
关键词：
herpesvirus; HDAC; IFI16; acetylation; NF-kappa B; p53; proteomics; metabolomics; chemoproteomics; EPSTEIN-BARR-VIRUS; B-DEPENDENT TRANSCRIPTION; ACTIVITY-BASED PROBES; SIMPLEX-VIRUS; HUMAN CYTOMEGALOVIRUS; GENE-EXPRESSION; SIGNAL-TRANSDUCTION; COREPRESSOR COMPLEX; PROTEIN-KINASE; FUNCTIONAL INTERACTION;
D O I：
10.3390/v5071607
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.
引用
收藏
页码：1607 / 1632
页数：26
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