Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis

被引:6
作者
Wang, Jun [1 ]
Guo, Xufeng [1 ]
Zhang, Jixiang [1 ]
Song, Jia [1 ]
Ji, Mengyao [1 ]
Yu, Shijie [1 ]
Wang, Jing [1 ]
Cao, Zhuo [1 ]
Dong, Weiguo [1 ]
机构
[1] Wuhan Univ, Renmin Hosp, Dept Gastroenterol, Wuhan 430060, Hubei, Peoples R China
关键词
Colorectal cancer; cyclooxygenase-2; polymorphism; meta-analysis; COLON-CANCER; GENE-EXPRESSION; GASTROINTESTINAL-TRACT; 3'-UNTRANSLATED REGION; COX-2; POLYMORPHISMS; AFRICAN-AMERICANS; MESSENGER-RNA; RISK; VARIANT; CARCINOGENESIS;
D O I
10.3349/ymj.2013.54.6.1353
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. Materials and Methods: All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study :by odds ratio (OR) together with its 95% confidence interval (CI), respectively. Results: A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A: OR=1.11, 95% CI: 0.82-1.51,p=0.78; -765G>C: OR=1.08, 95% CI: 0.96-1.21, p=0.07; 8473T>C: OR=1.03, 95% CI: 0.89-1.18, p=0.91; Val511Ala: OR=0.71, 95% CI: 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GO: OR=1.05, 95% CI: 0.87-1.28, p=0.03; GC+CC vs. GG: OR=1.08, 95% CI: 0.96-1.21, p=0.07). Conclusion: This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.
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收藏
页码:1353 / 1361
页数:9
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