Synthesis, Crystal Structure and Biological activity of N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

被引：0
作者：
Tong, Jian-Ying [1 ]
Sun, Na-Bo [1 ]
Wu, Hong-Ke [2 ]
Liu, Xing-Hai [2 ]
机构：
[1] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Crystal structure; synthesis; 1,3,4-thiadiazole; herbicidal activity; fungicidal activity; METAL-COMPLEXES; DERIVATIVES; MOIETY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new 1, 3, 4-thiadiazole compound, N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl) cyclopropanecarboxamide, was synthesized and its structure was confirmed by H-1 NMR, MS and HRMS. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound has moderate herbicidal activity against Brassica campestris and fungicidal activities against Sclerotinia sclerotiorum(Lib.) de Bary, Rhizoctonia solanii, Fusarium oxysporum, Corynespora cassiicola, and Botrytis cinerea.
引用
收藏
页码：1349 / 1353
页数：5
相关论文
共 16 条
[1]   Synthesis and characterization of new polyhydrazides based on 2,5-bis(mercapto-acetichydrazide)-1,3,4-thiadiazole moiety [J].
Al-Mulaikel, NS ;
El-Emary, TI .
EUROPEAN POLYMER JOURNAL, 2003, 39 (02) :211-218
[2]   Synthesis, characterization and antimicrobial activity evaluation of new 2,4-Thiazolidinediones bearing imidazo[2,1-b][1,3,4]thiadiazole moiety [J].
Alagawadi, Kallanagouda R. ;
Alegaon, Shankar G. .
ARABIAN JOURNAL OF CHEMISTRY, 2011, 4 (04) :465-472
[3]   Synthesis, structure, and biological activity of novel (oxdi/tri)azoles derivatives containing 1,2,3-thiadiazole or methyl moiety [J].
Liu, Xing-Hai ;
Pan, Li ;
Weng, Jian-Quan ;
Tan, Cheng-Xia ;
Li, Yong-Hong ;
Wang, Bao-Lei ;
Li, Zheng-Ming .
MOLECULAR DIVERSITY, 2012, 16 (02) :251-260
[4]  
Liu XH, 2011, ASIAN J CHEM, V23, P4064
[5]   SYNTHESIS, DIMERIC CRYSTAL STRUCTURE, AND FUNGICIDAL ACTIVITY OF 1-(4-METHYLPHENYL)-2-(5-((3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHYL)-4-PHENYL-4H-1,2,4-TRIAZOL-3-YLTHIO)ETHANONE [J].
Liu, Xing-Hai ;
Tan, Cheng-Xia ;
Weng, Jian-Quan .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (03) :558-564
[6]   PHASE TRANSFER-CATALYZED, ONE-POT SYNTHESIS OF SOME NOVEL N-PYRIMIDINYL-N′-NICOTINYL THIOUREA DERIVATIVES [J].
Liu, Xing-Hai ;
Tan, Cheng-Xia ;
Weng, Jian-Quan .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (03) :552-557
[7]   High Throughput Receptor-Based Virtual Screening Under ZINC Database, Synthesis, and Biological Evaluation of Ketol-Acid Reductoisomerase Inhibitors [J].
Liu, Xing-Hai ;
Chen, Pei-Quan ;
Wang, Bao-Lei ;
Dong, Wei-Li ;
Li, Yong-Hong ;
Xie, Xing-Qiao ;
Li, Zheng-Ming .
CHEMICAL BIOLOGY & DRUG DESIGN, 2010, 75 (02) :228-232
[8]   Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3, 4-thiadiazol-2-yl)cyclopropanecarboxamides [J].
Liu, Xing-Hai ;
Shi, Yan-Xia ;
Ma, Yi ;
Zhang, Chuan-Yu ;
Dong, Wei-Li ;
Pan, Li ;
Wang, Bao-Lei ;
Li, Bao-Ju ;
Li, Zheng-Ming .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (07) :2782-2786
[9]   Synthesis and Biological Activities on Metal Complexes of 2,5-Diamino-1,3,4-thiadiazole Derived from Semicarbazide Hydrochloride [J].
Obaleye, Joshua A. ;
Adediji, Johnson F. ;
Adebayo, Matthew A. .
MOLECULES, 2011, 16 (07) :5861-5874
[10]   Synthesis and Antifungal Activity of 1,2,4-triazole Derivatives Containing Cyclopropane Moiety [J].
Tan, Cheng-Xia ;
Shi, Yan-Xia ;
Weng, Jian-Quan ;
Liu, Xing-Hai ;
Li, Bao-Ju ;
Zhao, Wei-Guang .
LETTERS IN DRUG DESIGN & DISCOVERY, 2012, 9 (04) :431-435
12