Nontypeable Haemophilus influenzae: the role of N-acetyl-5-neuraminic acid in biology

被引：30
作者：
Apicella, Michael A. [1 ,2 ]
机构：
[1] Univ Iowa, Carver Coll Med, Dept Microbiol, Iowa City, IA 52242 USA
[2] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2012年 / 2卷
关键词：
nontypeable Haemophilus influenzae; Neu5Ac; sialic acid; sialyltransferases; N-ACETYLNEURAMINIC ACID; ESCHERICHIA-COLI K1; SIALIC-ACID; SERUM RESISTANCE; GLYCOLYLNEURAMINIC ACID; TRANS-SIALIDASE; GROUP-B; LIPOOLIGOSACCHARIDE; LIPOPOLYSACCHARIDE; IDENTIFICATION;
D O I：
10.3389/fcimb.2012.00019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nontypeable Haemophilus influenzae (NTHi) is an exclusive human pathogen, which has evolved a number of unique mechanisms to survive within the human environment. An important part of this is the ability of the organism to take up and incorporate sialic acid into its surface structures. This protects the organism against host adaptive and innate immune factor as well as serving as a mechanism for sustaining itself within biofilms. Recent evidence suggests that this also may be the source of the evolution of human antibodies to non-human sialic acid structures, which can lead to inflammation in the host. In very rare instances, evolution of antibodies to sialylated lipooligosaccharide (LOS) mimics of human antigens can result in autoimmune disease.
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