Klyflaccicembranols A-I, New Cembranoids from the Soft Coral Klyxum flaccidum

被引：13

作者：

Ahmed, Atallah F. ^{[1
,2
,3
]}

Tsai, Chia-Ruei ^{[1
]}

Huang, Chiung-Yao ^{[1
]}

Wang, Sheng-Yang ^{[4
]}

Sheu, Jyh-Horng ^{[1
,5
,6
,7
,8
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan

[2] King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia

[3] Mansoura Univ, Dept Pharmacognosy, Fac Pharm, Mansoura 35516, Egypt

[4] Natl Chung Hsing Univ, Dept Forestry, Taichung 40227, Taiwan

[5] Kaohsiung Med Univ, Inst Nat Prod, Kaohsiung 80756, Taiwan

[6] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 40402, Taiwan

[7] Natl Sun Yat Sen Univ, Frontier Ctr Ocean Sci & Technol, Kaohsiung 80424, Taiwan

[8] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan

来源：

MARINE DRUGS | 2017年 / 15卷 / 01期

关键词：

soft coral; Klyxum flaccidum; cembranoid; NO inhibition; cytotoxicity; EUNICELLIN-BASED DITERPENOIDS; MARINE TERPENES; SARCOPHYTON-GLAUCUM; LOBOPHYTUM-CRASSUM; NITRIC-OXIDE; SIMPLEX; GIBBEROSA; STEROIDS; MOLLE;

D O I：

10.3390/md15010023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New cembranoids klyflaccicembranols A-I (1-9), along with gibberosene D (10), have been isolated from the organic extract of a Formosan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analyses, including 2D NMR spectroscopy, and spectral data comparison with related structures. The cytotoxicity of the isolated metabolites, as well as their nitric oxide (NO) inhibitory activity, were evaluated and reported. Metabolites 2, 4, 6, 8 and 9 were found to exhibit variable activities against a limited panel of cancer cell lines in a range of IC50 16.5-49.4 mu M. Among the tested cembranoids, compounds 4, 5, 6, and 9 significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages at a dose of 50 mu g/mL.

引用

页数：16

共 29 条

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