Human Milk Glycoproteins Protect Infants Against Human Pathogens

被引：121
作者：
Liu, Bo [1 ]
Newburg, David S. [1 ]
机构：
[1] Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA
来源：
BREASTFEEDING MEDICINE | 2013年 / 8卷 / 04期
基金：
美国国家卫生研究院;
关键词：
SALT-STIMULATED LIPASE; HUMAN-IMMUNODEFICIENCY-VIRUS; FAT-GLOBULE-MEMBRANE; ESCHERICHIA-COLI; BREAST-MILK; SECRETORY IGA; HELICOBACTER-PYLORI; HAEMOPHILUS-INFLUENZAE; MOLECULAR-STRUCTURE; BINDING-PROPERTIES;
D O I：
10.1089/bfm.2013.0016
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Breastfeeding protects the neonate against pathogen infection. Major mechanisms of protection include human milk glycoconjugates functioning as soluble receptor mimetics that inhibit pathogen binding to the mucosal cell surface, prebiotic stimulation of gut colonization by favorable microbiota, immunomodulation, and as a substrate for bacterial fermentation products in the gut. Human milk proteins are predominantly glycosylated, and some biological functions of these human milk glycoproteins (HMGPs) have been reported. HMGPs range in size from 14 kDa to 2,000 kDa and include mucins, secretory immunoglobulin A, bile salt-stimulated lipase, lactoferrin, butyrophilin, lactadherin, leptin, and adiponectin. This review summarizes known biological roles of HMGPs that may contribute to the ability of human milk to protect neonates from disease.
引用
收藏
页码：354 / 362
页数：9
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