The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary study

被引：10
作者：
Han, Changwoo [1 ]
Bae, Hwallip [2 ]
Won, Sung-Doo [3 ]
Roh, Sungwon [4 ]
Kim, Dai-Jin [5 ]
机构：
[1] Korea Univ, Ansan Hosp, Coll Med, Dept Psychiat, Ansan, South Korea
[2] Seonam Univ, Myongji Hosp, Dept Psychiat, Goyang, South Korea
[3] Keyo Hosp, Keyo Med Fdn, Uiwang, South Korea
[4] Seoul Natl Hosp, Dept Mental Hlth Res, Seoul, South Korea
[5] Catholic Univ, Seoul St Marys Hosp, Coll Med, Dept Psychiat, Seoul 137701, South Korea
来源：
ANNALS OF GENERAL PSYCHIATRY | 2015年 / 14卷
关键词：
Alcohol dependence; Cognitive function; Brain-derived neurotrophic factor; NEUROPSYCHOLOGICAL DEFICITS; ETHANOL-CONSUMPTION; SERUM-LEVELS; BDNF; SCHIZOPHRENIA; DEPRESSION; PROBDNF; CONSORTIUM; ADDICTION; ESTABLISH;
D O I：
10.1186/s12991-015-0065-z
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Background: As a neurotoxic substance, alcohol can induce neurodegenesis in the brain. Alcohol-dependent patients' cognitive functioning can be affected by chronic alcohol use. In addition, brain-derived neurotrophic factor (BDNF) is known to reflect the status of neuroadaptive changes. The purpose of this study was to investigate the relationship between cognitive functions and BDNF in alcohol-dependent patients. Methods: The subjects were 39 alcohol-dependent patients. BDNF was measured using an enzyme-linked immunosorbent assay kit. We examined clinical features and administered the Korean version of Alcohol Dependence Scale. We also used the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) to measure cognitive functioning. Then, we determined the relationships between BDNF and various parts of the CERAD. Results: The performance of alcohol-dependent patients proved stable in most parts of the CERAD. Within the different parts of the CERAD, only Trail Making Test B correlated with BDNF. Trail Making Test specifically assesses executive functions. Conclusions: BDNF might play an important role in the detection of neurocognitive function among individuals with alcohol dependence.
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页数：6
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