Internal heavy atom effect of Au(III) and Pt(IV) on hypocrellin A for enhanced in vitro photodynamic therapy of cancer

被引：23
|
作者：
Zhou, Lin [1 ]
Ge, Xuefeng [1 ]
Liu, Jihua [2 ]
Zhou, Jiahong [1 ]
Wei, Shaohua [1 ]
Li, Fuyou [3 ,4 ,5 ]
Shen, Jian [1 ]
机构：
[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Coll Chem & Mat Sci,Key Lab Appl Photochem, Jiangsu Key Lab Biofunct Mat,Anal & Testing Ctr, Nanjing 210023, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Complex Prescript TCM, State Key Lab Nat Med, Nanjing 210038, Jiangsu, Peoples R China
[3] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[4] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
[5] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Internal heavy atom effect; Hypocrellin A; Complex; Intersystem crossing; Anticancer activity; MODIFIED SILICA NANOPARTICLES; CHELATION; COMPLEXES; IONS; DRUG; PHOTOSENSITIZER; LYSOZYME;
D O I：
10.1016/j.bmcl.2013.07.064
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hypocrellin A (HA), an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex, which exhibits enhanced O-1(2) generation quantum yield through the increased intersystem crossing efficiency mediated by internal heavy atom effect. Besides, the chelate process greatly improved the water solubility of HA. Comparative studies with HA and complexes have demonstrated that the heavy-atom effect on HA molecules enhances the efficiency of in vitro photodynamic (PDT) efficacy. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5317 / 5324
页数：8
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