Structure and function of the β subunit of voltage-gated Ca2+ channels

被引：96

作者：

Buraei, Zafir ^{[1
]}

Yang, Jian ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2013年 / 1828卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Ion channel; Auxiliary subunit; Calcium channel; Neuron; Synapse; Voltage-gated; I-II-LINKER; SENSITIVE CALCIUM-CHANNEL; ARACHIDONIC-ACID; ALPHA(1) SUBUNIT; MOLECULAR DETERMINANTS; GUANYLATE KINASE; AMINO-TERMINUS; DEPENDENT MODULATION; ANTISENSE DEPLETION; AUXILIARY SUBUNITS;

D O I：

10.1016/j.bbamem.2012.08.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The voltage-gated Ca2+ channel beta subunit (Ca-v beta) is a cytosolic auxiliary subunit that plays an essential role in regulating the surface expression and gating properties of high-voltage activated (HVA) Ca2+ channels. It is also crucial for the modulation of HVA Ca2+ channels by G proteins, kinases, Ras-related RGK GTPases, and other proteins. There are indications that Ca-v beta may carry out Ca2+ channel-independent functions. Ca-v beta knockouts are either non-viable or result in a severe pathophysiology, and mutations in Ca-v beta have been implicated in disease. In this article, we review the structure and various biological functions of Ca-v beta as well as recent advances. This article is part of a Special Issue entitled: Calcium channels. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：1530 / 1540

页数：11

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