CYTOGENETIC FINDINGS IN MENTALLY RETARDED IRANIAN PATIENTS

被引：6

作者：

Nasiri, F. ^{[1
]}

Mahjoubi, F. ^{[1
,2
]}

Manouchehry, F. ^{[1
]}

Razazian, F. ^{[1
]}

Mortezapour, F. ^{[1
]}

Rahnama, M. ^{[1
]}

机构：

[1] Iran Blood Transfus Org IBTO Res Ctr, High Inst Res & Educ Transfus Med, Dept Genet, Tehran, Iran

[2] Natl Res Inst Genet Engn & Biotechnol, Dept Clin Genet, Tehran, Iran

来源：

BALKAN JOURNAL OF MEDICAL GENETICS | 2012年 / 15卷 / 02期

关键词：

Chromosome abnormality; Idiopathic mental retardation (MR); Iranian patients; RETARDATION; CHILDREN; CHROMOSOME; TAIWAN;

D O I：

10.2478/bjmg-2013-0004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood Transfusion Organisation (IBTO) Research Centre, Tehran, Iran; these were performed on blood samples using conventional staining methods. Chromosome anomalies were identified in 205 of the patients (23.6%). The majority were Down's syndrome cases (n = 138). In 33 males, a positive fragile X anomaly was found. The remainder (n = 34) had other chromosomal abnormalities including structural chromosome aberrations (n = 23), marker chromosomes with an unknown origin (n = 3), sex chromosome aneuploidy (n = 6) and trisomy 18 (n = 2). The contribution of chromosome aberrations to the cause of MR in this group of patients is discussed.

引用

页码：29 / 34

页数：6

共 18 条

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