Phytochemicals of Cinnamomi Cortex: Cinnamic Acid, but not Cinnamaldehyde, Attenuates Oxaliplatin-Induced Cold and Mechanical Hypersensitivity in Rats

被引:31
作者
Chae, Hyeon Kyeong [1 ]
Kim, Woojin [2 ]
Kim, Sun Kwang [1 ,2 ]
机构
[1] Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea
[2] Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 02447, South Korea
关键词
Cinnamomi Cortex; phytochemical; cinnamic acid; cinnamaldehyde; oxaliplatin; neuropathic pain; allodynia; spinal cord; wide dynamic range neuron; INDUCED PERIPHERAL NEUROPATHY; PAINFUL NEUROPATHY; ALLODYNIA; FLUOROURACIL; LEUCOVORIN; INHIBITION; TRPA1;
D O I
10.3390/nu11020432
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
A chemotherapy drug, oxaliplatin, induces cold and mechanical hypersensitivity, but effective treatments for this neuropathic pain without side effects are still lacking. We previously showed that Cinnamomi Cortex suppresses oxaliplatin-induced pain behaviors in rats. However, it remains unknown which phytochemical of Cinnamomi Cortex plays a key role in that analgesic action. Thus, here we investigated whether and how cinnamic acid or cinnamaldehyde, major components of Cinnamomi Cortex, alleviates cold and mechanical allodynia induced by a single oxaliplatin injection (6 mg/kg, i.p.) in rats. Using an acetone test and the von Frey test for measuring cold and mechanical allodynia, respectively, we found that administration of cinnamic acid, but not cinnamaldehyde, at doses of 10, 20 and 40 mg/kg (i.p.) significantly attenuates the allodynic behaviors in oxaliplatin-injected rats with the strongest effect being observed at 20 mg/kg. Our in vivo extracellular recordings also showed that cinnamic acid (20 mg/kg, i.p.) inhibits the increased activities of spinal wide dynamic range neurons in response to cutaneous mechanical and cold stimuli following the oxaliplatin injection. These results indicate that cinnamic acid has an effective analgesic action against oxaliplatin-induced neuropathic pain through inhibiting spinal pain transmission, suggesting its crucial role in mediating the effect of Cinnamomi Cortex.
引用
收藏
页数:10
相关论文
共 50 条
[41]   Gosha-jinki-gan reduced oxaliplatin-induced hypersensitivity to cold sensation and its effect would be related to suppression of the expression of TRPM8 and TRPA1 in rats [J].
Kato, Yoshinori ;
Tateai, Yoshikazu ;
Ohkubo, Misao ;
Saito, Yuka ;
Amagai, Syun-ya ;
Kimura, Yu-suke ;
Iimura, Naohumi ;
Okada, Megumi ;
Matsumoto, Akiko ;
Mano, Yasunari ;
Hirosawa, Iori ;
Ohuchi, Kaori ;
Tajima, Masataka ;
Asahi, Mariko ;
Kotaki, Hajime ;
Yamada, Harumi .
ANTI-CANCER DRUGS, 2014, 25 (01) :39-43
[42]   Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats [J].
Aoki, Manahito ;
Mori, Asami ;
Nakahara, Tsutomu ;
Sakamoto, Kenji ;
Ishii, Kunio .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 696 (1-3) :62-69
[43]   Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats [J].
Shirahama, Masafumi ;
Ushio, Soichiro ;
Egashira, Nobuaki ;
Yamamoto, Shota ;
Sada, Hikaru ;
Masuguchi, Ken ;
Kawashiri, Takehiro ;
Oishi, Ryozo .
MOLECULAR PAIN, 2012, 8
[44]   Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats [J].
Y.-L. Hsieh ;
Y.-C. Fan ;
C.-C. Yang .
Supportive Care in Cancer, 2016, 24 :233-242
[45]   MiR-30b-5p attenuates oxaliplatin-induced peripheral neuropathic pain through the voltage-gated sodium channel Nav1.6 in rats [J].
Li, Lei ;
Shao, Jinping ;
Wang, Jiangshuan ;
Liu, Yaping ;
Zhang, Yidan ;
Zhang, Mengya ;
Zhang, Jingjing ;
Ren, Xiuhua ;
Su, Songxue ;
Li, Yunqing ;
Cao, Jing ;
Zang, Weidong .
NEUROPHARMACOLOGY, 2019, 153 :111-120
[46]   Deficiency of KIF15 contributes to oxaliplatin-induced cold hypersensitivity by limiting annexin A2 and enhancing TRPA1 localization in DRG neuronal membrane [J].
Wu, Liu-Ying ;
Zhai, Meng-Nan ;
Bai, Xue-Qiang ;
He, Cheng ;
Guo, Yun-Ying ;
Zhang, Yu-Qi ;
Wang, Juan ;
Gao, Yong-Tao ;
Tu, Qi-Feng ;
Liu, Mei ;
Chen, Jun-Jie ;
Zhang, Zhi-Jun .
NEUROPHARMACOLOGY, 2025, 269
[47]   Nicotinic Acetylcholine Receptors Mediate the Suppressive Effect of an Injection of Diluted Bee Venom into the GV3 Acupoint on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats [J].
Yoon, Heera ;
Kim, Min Joon ;
Yoon, Insoo ;
Li, Dong Xing ;
Bae, Hyunsu ;
Kim, Sun Kwang .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2015, 38 (05) :710-714
[48]   Spinal cord stimulation prevents paclitaxel-induced mechanical and cold hypersensitivity and modulates spinal gene expression in rats [J].
Sivanesan, Eellan ;
Stephens, Kimberly E. ;
Huang, Qian ;
Chen, Zhiyong ;
Ford, Neil C. ;
Duan, Wanru ;
He, Shao-Qui ;
Gao, Xinyan ;
Linderoth, Bengt ;
Raja, Srinivasa N. ;
Guan, Yun .
PAIN REPORTS, 2019, 4 (05)
[49]   Spinal cord stimulation attenuates paclitaxel-induced gait impairment and mechanical hypersensitivity via peripheral neuroprotective mechanisms in tumor-bearing rats [J].
Bakare, Ahmed Olalekan ;
Stephens, Kimberly ;
Sanchez, Karla R. ;
Liu, Vivian ;
Zheng, Lei ;
Goel, Vasudha ;
Guan, Yun ;
Sivanesan, Eellan .
REGIONAL ANESTHESIA AND PAIN MEDICINE, 2024,
[50]   Combination of ellagic acid and trans-cinnamaldehyde alleviates aging-induced cognitive impairment via modulation of mitochondrial function and inflammatory and apoptotic mediators in the prefrontal cortex of aged rats [J].
Pan, Zengjun ;
He, Xining ;
Zhou, Xianwen ;
Li, Xiaoqiang ;
Rong, Bo ;
Wang, Fenglu .
CHINESE JOURNAL OF PHYSIOLOGY, 2020, 63 (05) :218-226