Phytochemicals of Cinnamomi Cortex: Cinnamic Acid, but not Cinnamaldehyde, Attenuates Oxaliplatin-Induced Cold and Mechanical Hypersensitivity in Rats

被引:27
作者
Chae, Hyeon Kyeong [1 ]
Kim, Woojin [2 ]
Kim, Sun Kwang [1 ,2 ]
机构
[1] Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea
[2] Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul 02447, South Korea
来源
NUTRIENTS | 2019年 / 11卷 / 02期
关键词
Cinnamomi Cortex; phytochemical; cinnamic acid; cinnamaldehyde; oxaliplatin; neuropathic pain; allodynia; spinal cord; wide dynamic range neuron; INDUCED PERIPHERAL NEUROPATHY; PAINFUL NEUROPATHY; ALLODYNIA; FLUOROURACIL; LEUCOVORIN; INHIBITION; TRPA1;
D O I
10.3390/nu11020432
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
A chemotherapy drug, oxaliplatin, induces cold and mechanical hypersensitivity, but effective treatments for this neuropathic pain without side effects are still lacking. We previously showed that Cinnamomi Cortex suppresses oxaliplatin-induced pain behaviors in rats. However, it remains unknown which phytochemical of Cinnamomi Cortex plays a key role in that analgesic action. Thus, here we investigated whether and how cinnamic acid or cinnamaldehyde, major components of Cinnamomi Cortex, alleviates cold and mechanical allodynia induced by a single oxaliplatin injection (6 mg/kg, i.p.) in rats. Using an acetone test and the von Frey test for measuring cold and mechanical allodynia, respectively, we found that administration of cinnamic acid, but not cinnamaldehyde, at doses of 10, 20 and 40 mg/kg (i.p.) significantly attenuates the allodynic behaviors in oxaliplatin-injected rats with the strongest effect being observed at 20 mg/kg. Our in vivo extracellular recordings also showed that cinnamic acid (20 mg/kg, i.p.) inhibits the increased activities of spinal wide dynamic range neurons in response to cutaneous mechanical and cold stimuli following the oxaliplatin injection. These results indicate that cinnamic acid has an effective analgesic action against oxaliplatin-induced neuropathic pain through inhibiting spinal pain transmission, suggesting its crucial role in mediating the effect of Cinnamomi Cortex.
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页数:10
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