The Long-term Effects of Open and Endovascular Aneurysm Repair on Circulating Interleukin-6

被引：7

作者：

Dawson, J. A. ^{[1
]}

Choke, E. ^{[1
]}

Cockerill, G. W. ^{[1
]}

Loftus, I. M. ^{[1
]}

Thompson, M. M. ^{[1
]}

机构：

[1] St George Hosp, St Georges Vasc Inst, London SW17 0RE, England

来源：

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | 2009年 / 37卷 / 01期

关键词：

Abdominal aortic aneurysm; Interleukin-6; Endovascular aneurysm repair; Cardiovascular mortality; ABDOMINAL AORTIC-ANEURYSMS;

D O I：

10.1016/j.ejvs.2008.09.025

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Interleukin-6 (IL-6) is associated with abdominal aortic aneurysm (AAA) development and is an independent risk factor for cardiovascular mortality. We tested the hypothesis that aneurysm repair reduces circulating IL-6 by comparing concentrations in patients with large AAA awaiting repair (n = 50) with patients having undergone open (n = 34) or endovascular (n = 66) repair. Only open repair was associated with a significant reduction in IL-6 (p = 0.025). These results suggest that AAAs remain biologically active following endovascular repair. Aneurysm-derived IL-6 may have serious implications for cardiovascular health, and attention should be directed to modifying cardiovascular risk factors in these patients, even after successful aneurysm repair. (c) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

引用

页码：43 / 45

页数：3

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