Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

被引：210

作者：

Huang, Cheng ^{[1
,2
]}

Fu, Yuan ^{[1
]}

Fu, Hua ^{[1
]}

Jiang, Yuyang ^{[1
,2
]}

Zhao, Yufen ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Grad Sch, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 47期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/b814011a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.

引用

页码：6333 / 6335

页数：3

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