The role of metal ions in amyloid formation: general principles from model peptides

被引：45
|
作者：
Alies, Bruno [1 ,2 ]
Hureau, Christelle [1 ,2 ]
Faller, Peter [1 ,2 ]
机构：
[1] CNRS, LCC, F-31077 Toulouse 4, France
[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
来源：
METALLOMICS | 2013年 / 5卷 / 03期
关键词：
ALZHEIMERS-DISEASE; BETA PEPTIDES; A-BETA; NEURODEGENERATIVE DISEASES; PRECURSOR PROTEIN; PRION DISEASES; BINDING; COORDINATION; ZINC; KINETICS;
D O I：
10.1039/c3mt20219d
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanistic understanding of peptide self-assembly mediated by metal ions into amyloids or other structures has gained a lot of interest, mainly due to their importance in several neurodegenerative diseases. The use of short, easy-to-handle peptides has contributed to a better knowledge of structures and mechanisms that are also relevant for the native and longer peptides involved in the neurodegenerative diseases. Here, we review the results obtained with such "model systems" with the aim to identify and discuss fundamental parameters determining the self-aggregation with a special focus on the role of metal ions in this process.
引用
收藏
页码：183 / 192
页数：10
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