Gene delivery polymer structure-function relationships elucidated via principal component analysis

被引：27

作者：

Bishop, C. J. ^{[1
]}

Abubaker-Sharif, B. ^{[1
]}

Guiriba, T. ^{[2
]}

Tzeng, S. Y. ^{[1
]}

Green, J. J. ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Translat Tissue Engn Ctr, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 60期

关键词：

DNA; NANOPARTICLES; CANCER; SIRNA;

D O I：

10.1039/c5cc04417k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

引用

页码：12134 / 12137

页数：4

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