Interaction of mononuclear nickel(II) enantiomers, Δ- and Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine)nickel(II) chloride, with calf thymus DNA

被引：2
|
作者：
Hadadzadeh, Hassan [1 ]
Daryanavard, Marzieh [1 ,2 ]
Morshedi, Mahbod [3 ]
机构：
[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran
[2] Univ Toronto, Dept Chem & Phys Sci, Mississauga, ON L5L 1C6, Canada
[3] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia
来源：
INORGANICA CHIMICA ACTA | 2013年 / 400卷
关键词：
Nickel(II) complex; Dipyrido[3,2-a:2 ',3 '-c]phenazine (dppz); Chiral precursor; DNA binding; Enantiomer; Circular dichroism (CD); LIGAND RUTHENIUM(II) COMPLEXES; PHOTOINDUCED ELECTRON-TRANSFER; LIGHT-SWITCH; METAL-COMPLEXES; THREADING INTERCALATION; COOPERATIVE BINDING; CIRCULAR-DICHROISM; ACID; PROBE;
D O I：
10.1016/j.ica.2013.02.010
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Circular dichroism (CD) spectroscopy was used to investigate the interaction of Delta- and Lambda-enantiomers of a mononuclear Ni(II) complex, [Ni(phen)(2)(dppz)](2+) (where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2',3'-c]phenazine), with CT-DNA. The pure Ni(II) enantiomers were synthesized via a chiral precursor. The changes in the absorption and CD spectra upon binding provide detailed information about DNA binding of the enantiomers. The change in the CD spectra over time was used to calculate the racemization rates in the absence and presence of DNA. It was observed that the Delta-enantiomer racemizes slower than the Lambda-enantiomer in the presence of DNA. Competition between the Ru(II) enantiomers, Delta- and Lambda-[Ru(phen)(2)(dppz)](2+), and the Ni(II) enantiomers, Delta- and Lambda-[Ni(phen)(2)(dppz)](2+), was also studied via luminescence titration. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：82 / 90
页数：9
相关论文
共 50 条
  • [41] Crystal structure of (bis(1,10-phenanthroline-κ2N,N′))-(3,5-dinitrosalicylato-κ2O,O′)nickel(II), C31H18N6NiO7
    Tang, Zhiwei
    Wu, Dewu
    Wen, Decai
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2022, 237 (06): : 981 - 983
  • [42] Studies on one 2D cadmium(II) coordination polymer and two mononuclear cadmium(II) complexes with trans or cis configuration having 3-bromo, 3,6-dibromo, and 3,8-dibromo 1,10-phenanthroline ligands
    Wang, Li
    You, Wei
    Huang, Wei
    JOURNAL OF MOLECULAR STRUCTURE, 2009, 920 (1-3) : 270 - 276
  • [43] Synthesis, characterization, and DNA binding, photocleavage, cytotoxicity, cellular uptake, apoptosis, and on-off light switching studies of Ru(II) mixed-ligand complexes containing 7-fluorodipyrido[3,2-a:2′,3′-c]phenazine
    Deepika, Nancherla
    Kumar, Yata Praveen
    Devi, Chittimalli Shobha
    Reddy, Putta Venkat
    Srishailam, Avudoddi
    Satyanarayana, Sirasani
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2013, 18 (07): : 751 - 766
  • [44] Solid state synthesis of NiO nanoparticles from [(1,2-bis(2-formyl-3-methoxyphenyl)propane)nickel(II)] chloride
    Khalaji, Aliakbar Dehno
    Gharib, Fatemeh
    IRANIAN CHEMICAL COMMUNICATION, 2016, 4 (03) : 265 - 272
  • [45] The mononuclear nickel(II) complex bis(azido-κN)bis[2,5-bis(pyridin-2-yl)-1,3,4-thiadiazole-κ2N2,N3]nickel(II) protects tomato from Verticillium dahliae by inhibiting fungal growth and activating plant defences
    Zine, Hanane
    Rifai, Lalla Aicha
    Koussa, Tayeb
    Bentiss, Fouad
    Guesmi, Salaheddine
    Laachir, Abdelhakim
    Makroum, Kacem
    Belfaiza, Malika
    Faize, Mohamed
    PEST MANAGEMENT SCIENCE, 2017, 73 (01) : 188 - 197
  • [46] A copper(II) complex of the Schiff base from L-valine and 2-hydroxy-1-naphthalidene plus 1,10-phenanthroline: synthesis, crystal structure, and DNA interaction
    Li, Jinghong
    Dong, Jianfang
    Cui, Hui
    Xu, Tao
    Li, Lianzhi
    TRANSITION METAL CHEMISTRY, 2012, 37 (02) : 175 - 182
  • [47] Hydrothermal synthesis and crystal structure of catena-poly[(1,10-phenanthroline-κ2N,N′)-bis(μ2-nitroisophthalato-κ3O,O′:O")nickel(II)], C20H13NiN3O7
    Bi, Wen-Jie
    Dong, Xie
    Hu, Xing-ming
    Hu, Chen
    Bian, He-dong
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2025, 240 (01): : 11 - 13
  • [48] catena-Poly[[chlorido(1,10-phenanthroline)copper(II)]-μ-{2-[(1S,3S)-3-acetyl-2,2-dimethylcyclobutyl]acetato}]
    Ma, Shi-ying
    Li, Yan-fei
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : M1789 - U1876
  • [49] Novel 10,13-disubstituted dipyrido[3,2-a:2',3'-c]phenazines and their platinum(II) complexes: highly luminescent ICT-type fluorophores based on D-A-D structures
    Shigehiro, Tatsuya
    Yagi, Shigeyuki
    Maeda, Takeshi
    Nakazumi, Hiroyuki
    Fujiwara, Hideki
    Sakurai, Yoshiaki
    TETRAHEDRON LETTERS, 2014, 55 (37) : 5195 - 5198
  • [50] Synthesis, characterization, and DNA binding, photocleavage, cytotoxicity, cellular uptake, apoptosis, and on–off light switching studies of Ru(II) mixed-ligand complexes containing 7-fluorodipyrido[3,2-a:2′,3′-c]phenazine
    Nancherla Deepika
    Yata Praveen Kumar
    Chittimalli Shobha Devi
    Putta Venkat Reddy
    Avudoddi Srishailam
    Sirasani Satyanarayana
    JBIC Journal of Biological Inorganic Chemistry, 2013, 18 : 751 - 766
12345