Interaction of mononuclear nickel(II) enantiomers, Δ- and Λ-bis(1,10-phenanthroline) (dipyrido[3,2-a:2′,3′-c]phenazine)nickel(II) chloride, with calf thymus DNA

被引：2
|
作者：
Hadadzadeh, Hassan [1 ]
Daryanavard, Marzieh [1 ,2 ]
Morshedi, Mahbod [3 ]
机构：
[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran
[2] Univ Toronto, Dept Chem & Phys Sci, Mississauga, ON L5L 1C6, Canada
[3] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia
来源：
INORGANICA CHIMICA ACTA | 2013年 / 400卷
关键词：
Nickel(II) complex; Dipyrido[3,2-a:2 ',3 '-c]phenazine (dppz); Chiral precursor; DNA binding; Enantiomer; Circular dichroism (CD); LIGAND RUTHENIUM(II) COMPLEXES; PHOTOINDUCED ELECTRON-TRANSFER; LIGHT-SWITCH; METAL-COMPLEXES; THREADING INTERCALATION; COOPERATIVE BINDING; CIRCULAR-DICHROISM; ACID; PROBE;
D O I：
10.1016/j.ica.2013.02.010
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Circular dichroism (CD) spectroscopy was used to investigate the interaction of Delta- and Lambda-enantiomers of a mononuclear Ni(II) complex, [Ni(phen)(2)(dppz)](2+) (where phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2',3'-c]phenazine), with CT-DNA. The pure Ni(II) enantiomers were synthesized via a chiral precursor. The changes in the absorption and CD spectra upon binding provide detailed information about DNA binding of the enantiomers. The change in the CD spectra over time was used to calculate the racemization rates in the absence and presence of DNA. It was observed that the Delta-enantiomer racemizes slower than the Lambda-enantiomer in the presence of DNA. Competition between the Ru(II) enantiomers, Delta- and Lambda-[Ru(phen)(2)(dppz)](2+), and the Ni(II) enantiomers, Delta- and Lambda-[Ni(phen)(2)(dppz)](2+), was also studied via luminescence titration. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：82 / 90
页数：9
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