A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system

被引：8
|
作者：
Guo, Ying [1 ]
Ji, Si-Zhe [2 ]
Chen, Cheng [1 ]
Liu, Hong-Wei [1 ]
Zhao, Jian-Hong [1 ]
Zheng, Yu-Lin [3 ]
Ji, Ya-Fei [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
[3] Shanghai New Asia Pharmaceut Co Ltd, Shanghai 201203, Peoples R China
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 11期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
Cu-catalysis; Unactivated aryl bromides; Methoxylation; Aryl methyl ethers; Recovery of pure MeOH; ALKYL ARYL; EFFICIENT; TRIMETHOPRIM; METHANOLYSIS; CATALYSIS; AIR;
D O I：
10.1007/s11164-014-1917-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.
引用
收藏
页码：8651 / 8664
页数：14
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