Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Triazole Derivatives

被引：9

作者：

Wang, Nan ^{[1
]}

Chai, Xiaoyun ^{[2
]}

Chen, Ying ^{[1
]}

Zhang, Lei ^{[1
]}

Li, Wenjuan ^{[1
]}

Gao, Yijun ^{[1
]}

Bi, Yi ^{[1
]}

Yu, Shichong ^{[1
,2
]}

Meng, Qingguo ^{[1
]}

机构：

[1] Yantai Univ, Dept Med Chem, Sch Pharm, Yantai 264005, Peoples R China

[2] Second Mil Med Univ, Sch Pharm, Dept Organ Chem, Shanghai 200433, Peoples R China

来源：

MEDICINAL CHEMISTRY | 2013年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Triazole; Carbonate; Synthesis; Antifungal activity; Molecular docking; FUNGAL-INFECTIONS; LANOSTEROL; 14-ALPHA-DEMETHYLATION; BIOLOGICAL EVALUATION; EPIDEMIOLOGY; RESISTANCE; AGENTS; METABOLISM; DESIGN; TRENDS; YEAST;

D O I：

10.2174/1573406411309030009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 3/4-[[N-alkyl-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1, 2, 4-triazole)] propylamino] benzylethyl carbonate were designed, synthesized and evaluated as antifungal agents. The MIC80 values indicate that all the compounds showed only moderate or even no antifungal activities against nearly all the tested fungal pathogens. Moreover, the interactions of the most active compounds in the drug binding site of CACYP51 were also explored with the help of docking studies.

引用

页码：384 / 388

页数：5

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