Interactions between ultrasound stimulated microbubbles and fibrin clots

被引：33
作者：
Acconcia, Christopher [1 ,2 ]
Leung, Ben Y. C. [2 ]
Hynynen, Kullervo [1 ,2 ]
Goertz, David E. [1 ,2 ]
机构：
[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A1, Canada
[2] Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
来源：
APPLIED PHYSICS LETTERS | 2013年 / 103卷 / 05期
基金：
加拿大自然科学与工程研究理事会;
关键词：
TISSUE-PLASMINOGEN ACTIVATOR; ACUTE ISCHEMIC-STROKE; IN-VITRO; BLOOD-CLOTS; TRANSCRANIAL ULTRASOUND; THROMBOLYSIS; SONOTHROMBOLYSIS; LYSIS; BUBBLES; VIVO;
D O I：
10.1063/1.4816750
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
While it is well established that ultrasound stimulated microbubbles (USMBs) can potentiate blood clot lysis, the mechanisms are not well understood. Here we examine the interaction between USMBs and fibrin clots, which are comprised of fibrin networks that maintain the mechanical integrity of blood clots. High speed camera observations demonstrated that USMBs can penetrate fibrin clots. Two-photon microscopy revealed that penetrating bubbles can leave behind patent "tunnels" along their paths and that fluid can be transported into the clots. Finally, it is observed that primary radiation forces associated with USMBs can induce local deformation and macroscopic translation of clot boundaries. (C) 2013 AIP Publishing LLC.
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页数：4
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