Ubiquitination of Na,K-ATPase alpha 1 and alpha 2 subunits

被引：26

作者：

Coppi, MV

Guidotti, G

机构：

[1] Dept. of Cell. and Molecular Biology, Fairchild Biochemistry Building, Harvard University, Cambridge, MA 02138

来源：

FEBS LETTERS | 1997年 / 405卷 / 03期

关键词：

Na; K-ATPase; ubiquitin; polytopic integral membrane protein; COS-7; cell; alpha subunit; proteasome;

D O I：

10.1016/S0014-5793(97)00182-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Na,K-ATPase, an essential transporter of mammalian cells, is an oligomeric transmembrane protein composed of two subunits, alpha and beta, of which there are several isoforms. In this study, me demonstrate that the alpha 1 and alpha 2 isoforms of the Na,K-ATPase alpha subunit are modified by the covalent attachment of ubiquitin polymers in COS-7 cells. We propose that polyubiquitination of the Na,K-ATPase alpha subunit may play a role in regulating its degradation. (C) 1997 Federation of European Biochemical Societies.

引用

页码：281 / 284

页数：4

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