Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia

被引：13
作者：
Bloom, Rachael J. [1 ]
Kahler, Anna K. [1 ,2 ,3 ]
Collins, Ann L. [1 ]
Chen, Guanhua [4 ]
Cannon, Tyrone D. [5 ,6 ]
Hultman, Christina [2 ]
Sullivan, Patrick F. [1 ,2 ,7 ]
机构：
[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[3] Oslo Univ Hosp Ulleval, Dept Psychiat, Oslo, Norway
[4] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA
[5] Yale Univ, Dept Psychol, New Haven, CT 06520 USA
[6] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
[7] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA
来源：
SCHIZOPHRENIA RESEARCH | 2013年 / 146卷 / 1-3期
关键词：
Schizophrenia; Bipolar disorder; Monozygotic twin; Discordant; Genetics; Copy number variation; Structural variation;
D O I：
10.1016/j.schres.2013.02.021
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：289 / 290
页数：2
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