CYTOKINES IN ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA

被引：102

作者：

Angelopoulos, P. ^{[1
]}

Agouridaki, H. ^{[2
]}

Vaiopoulos, H. ^{[1
]}

Siskou, E. ^{[2
]}

Doutsou, K. ^{[2
]}

Costa, V. ^{[2
,3
]}

Baloyiannis, S. I. ^{[2
,3
]}

机构：

[1] Gen Hosp Xanthi, Xanthi, Greece

[2] AHEPA Gen Hosp, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Thessaloniki, Greece

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 12期

关键词：

Age; Alzheimer's disease; cytokines; depression; hypertension; vascular dementia;

D O I：

10.1080/00207450701392068

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The levels of interleukin 1 beta, interleukin 6, and interleukin 10 were elevated in the serum of patients with dementia. No statistically significant correlation was recorded in the interleukin levels among patients with Alzheimer's disease and vascular dementia. Also, no significant correlation was observed in the interleukin levels in the serum and the severity of dementia. However, a significant correlation was found between IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels and age. The levels of IL-1 beta and IL-6 were positively correlated with hypertension, and IL-2 levels were negatively correlated. No correlation was found between depressive symptoms and levels of cytokines in the serum.

引用

页码：1659 / 1672

页数：14

共 36 条

[31] Inflammatory proteins and depression in the elderly [J].

Tiemeier, H ;

Hofman, A ;

van Tuijl, HR ;

Kiliaan, AJ ;

Meijer, J ;

Breteler, MMB .

EPIDEMIOLOGY, 2003, 14 (01) :103-107

[32] SERUM LEVELS OF INTERLEUKIN-6 ARE NOT ELEVATED IN PATIENTS WITH ALZHEIMERS-DISEASE [J].

VANDUIJN, CM ;

HOFMAN, A ;

NAGELKERKEN, L .

NEUROSCIENCE LETTERS, 1990, 108 (03) :350-354

[33] Residual lifetime risk for developing hypertension in middle-aged women and men - The Framingham Heart Study [J].

Vasan, RS ;

Beiser, A ;

Seshadri, S ;

Larson, MG ;

Kannel, WB ;

D'Agostino, RB ;

Levy, D .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (08) :1003-1010

[34]

VIJENDRA K, 1997, J PSYCHIATR RES, V6, P657

[35]

WRAGG RE, 1989, AM J PSYCHIAT, V146, P577

[36] DECREASED INTERLEUKIN-6 LEVEL IN THE CEREBROSPINAL-FLUID OF PATIENTS WITH ALZHEIMER-TYPE DEMENTIA [J].

YAMADA, K ;

KONO, K ;

UMEGAKI, H ;

YAMADA, K ;

IGUCHI, A ;

FUKATSU, T ;

NAKASHIMA, N ;

NISHIWAKI, H ;

SHIMADA, Y ;

SUGITA, Y ;

YAMAMOTO, T ;

HASEGAWA, T ;

NABESHIMA, T .

NEUROSCIENCE LETTERS, 1995, 186 (2-3) :219-221

← 1 2 3 4 →