Population meta-analysis of low plasma glucose thresholds in full-term normal newborns

被引:52
作者
Alkalay, AL
Sarnat, HB
Flores-Sarnat, L
Elashoff, JD
Farber, SJ
Simmons, CF
机构
[1] Cedars Sinai Med Ctr, Div Neonatol, Dept Pediat, Ahmanson Pediat Ctr, Los Angeles, CA 90048 USA
[2] Alberta Childrens Prov Gen Hosp, Dept Pediat, Div Neurol, Calgary, AB T2T 5C7, Canada
[3] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Cedars Sinai Med Ctr,David Geffen Sch Med, Los Angeles, CA USA
关键词
neonatal hypoglycemia; plasma glucose threshold; population meta-analysis;
D O I
10.1055/s-2006-931912
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
There is extreme variation in the definition of low plasma glucose levels in newborn infants in the first postnatal days, ranging from < 30 to <= 60 mg/dL. The goal of the present study was to define low thresholds (<= 5th percentile) of plasma glucose concentrations in full-term normal newborns during the first 72 hours of life. Population meta-analysis was performed on published studies of neonatal hypoglycemia ascertained by MedLine search. One-way analysis of variance was computed across the studies for each of the following four postnatal time periods: 1 to 2 (physiological nadir), 3 to 23, 24 to 47, and 48 to 72 hours. The estimated <= 5th percentiles of neonatal hypoglycemia during 1 to 2, 3 to 23, 24 to 47, and 48 to 72 hours after birth were <= 28, <= 40, <= 41, and <= 48 mg/dL, respectively. Based on this statistical definition, we recommend that low thresholds of plasma glucose levels of 28, 40, and 48 mg/dL be adopted in full-term normal newborns at 1 to 2, 3 to 47, and 48 to 72 hours of life, respectively.
引用
收藏
页码:115 / 119
页数:5
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