A prospective study of nutritional status in immunoglobulin light chain amyloidosis

被引：24

作者：

Sattianayagam, Prayman T. ^{[1
]}

Lane, Thirusha ^{[1
]}

Fox, Zoe ^{[2
]}

Petrie, Aviva ^{[3
]}

Gibbs, Simon D. J. ^{[1
]}

Pinney, Jennifer H. ^{[1
]}

Risom, Signe S. ^{[1
]}

Rowczenio, Dorota M. ^{[1
]}

Wechalekar, Ashutosh D. ^{[1
]}

Lachmann, Helen J. ^{[1
]}

Gilbertson, Janet A. ^{[1
]}

Hawkins, Philip N. ^{[1
]}

Gillmore, Julian D. ^{[1
]}

机构：

[1] UCL, Ctr Amyloidosis & Acute Phase Prot, Natl Amyloidosis Ctr, London WC1E 6BT, England

[2] UCL, Dept Populat Sci, Div Med, London WC1E 6BT, England

[3] UCL, Biostat Unit, Eastman Dent Inst, London WC1E 6BT, England

来源：

HAEMATOLOGICA | 2013年 / 98卷 / 01期

关键词：

QUALITY-OF-LIFE; SUBJECTIVE GLOBAL ASSESSMENT; PRIMARY SYSTEMIC AMYLOIDOSIS; STEM-CELL TRANSPLANTATION; ASSESSMENT PG-SGA; CANCER; MALNUTRITION; FEATURES;

D O I：

10.3324/haematol.2012.070359

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naive patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P<0.05). Quality of life was substantially poorer among those with higher PG-SGA scores (P<0.001). Furthermore, PG-SGA score was a powerful independent predictor of patient survival (P=0.02). Malnutrition is prevalent and is associated with poor quality of life and reduced survival among patients with systemic immunoglobulin light chain amyloidosis. The PG-SGA score would be an appropriate tool to evaluate whether nutritional intervention could improve patient outcomes. (C) 2013 Ferrata Storti Foundation. This is an open-access paper. doi:10.3324/haematol.2012.070359

引用

页码：136 / 140

页数：5

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