Acyl/free carnitine ratio is a risk factor for hepatic steatosis after pancreatoduodenectomy and total pancreatectomy

被引：8

作者：

Nakamura, Masafumi ^{[1
,3
]}

Nakata, Kohei ^{[1
]}

Matsumoto, Hideo ^{[3
]}

Ohtsuka, Takao ^{[1
]}

Yoshida, Koji ^{[4
]}

Tokunaga, Shoji ^{[2
]}

Hino, Keisuke ^{[4
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Med & Bioregulatmy Sci, Fukuoka, Japan

[3] Kawasaki Med Sch, Dept Digest Surg, Kurashiki, Okayama, Japan

[4] Kawasaki Med Sch, Dept Hepatol & Pancreatol, Kurashiki, Okayama, Japan

来源：

PANCREATOLOGY | 2017年 / 17卷 / 01期

关键词：

Acylcarnitine; Computed tomography; Hepatic steatosis; L-camitine; Pancreatectomy; FATTY LIVER; ANOREXIA-NERVOSA; PREVALENCE; SUPPLEMENTATION; STEATOHEPATITIS;

D O I：

10.1016/j.pan.2016.11.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: Hepatic steatosis, one of the most frequent long-term complications of pancreatectomy, influences not only hepatic function but also survival rate. However, its risk factors and pathogenesis have not been established. The purpose of this study was to clarify the risk factors for hepatic steatosis after pancreatectomy. Methods: In this retrospective study of 21 patients who had undergone pancreatectomy (19 cases of pancreatoduodenectomy and 2 cases of total pancreatectomy), serum carnitine concentrations, fractions of carnitine, and hepatic attenuation on computed tomography images were analyzed with the aim of identifying risk factors for hepatic steatosis. Results: Thirteen (61.9%) of the 21 patients were diagnosed as having hypocarnitinemia after pancreatectomy. Average hepatic attenuation was as low as 42.2HU (+/- 21.3 SD). A high ratio of acyl/free carnitine was associated with less pronounced hepatic attenuation according to both univariate (P < 0.001) and multivariate (P = 0.020) regression analyses. Conclusions: The serum carnitine concentrations were low after pancreatectomy in some patients. The statistical analyses suggest that a high ratio of acylifree carnitine is an independent risk factor for hepatic steatosis after pancreatectomy. (C) 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.

引用

页码：135 / 138

页数：4