Wired on sugar: the role of the CNS in the regulation of glucose homeostasis

被引：81

作者：

Grayson, Bernadette E. ^{[1
]}

Seeley, Randy J. ^{[1
]}

Sandoval, Darleen A. ^{[1
]}

机构：

[1] Univ Cincinnati, Metab Dis Inst, Cincinnati, OH 45237 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2013年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HEPATIC INSULIN SENSITIVITY; ACTIVATED PROTEIN-KINASE; REDUCES FOOD-INTAKE; K-ATP CHANNELS; BODY-WEIGHT; PROOPIOMELANOCORTIN NEURONS; LEPTIN ACTION; POMC NEURONS; INTRACEREBROVENTRICULAR INFUSION; DISTINCT POPULATIONS;

D O I：

10.1038/nrn3409

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Obesity and type 2 diabetes mellitus (T2DM)-disorders of energy homeostasis and glucose homeostasis, respectively-are tightly linked and the incidences of both conditions are increasing in parallel. The CNS integrates information regarding peripheral nutrient and hormonal changes and processes this information to regulate energy homeostasis. Recent findings indicate that some of the neural circuits and mechanisms underlying energy balance are also essential for the regulation of glucose homeostasis. We propose that disruption of these overlapping pathways links the metabolic disturbances associated with obesity and T2DM. A better understanding of these converging mechanisms may lead to therapeutic strategies that target both T2DM and obesity.

引用

页码：24 / 37

页数：14

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